Anthelmintic activity of nigella sativa against caenorhabditis elegans

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dc.authoridAbdullah Olgun / 0000-0002-6976-9286en_US
dc.authorscopusidAbdullah Olgun / 6603877209
dc.authorwosidAbdullah Olgun / FPP-8980-2022
dc.contributor.authorSen, Emine
dc.contributor.authorOgut, Tugce
dc.contributor.authorOlgun, Abdullah
dc.contributor.authorKisa, Ozgul
dc.date.accessioned2021-09-10T05:32:55Z
dc.date.available2021-09-10T05:32:55Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Eczacılık Fakültesi, Eczacılık Temel Bilimleri Bölümüen_US
dc.description.abstractIncreasing resistance against classical anthelmintic drugs makes discovering new anthelmintic compounds from natural plants important. Nigella sativa (N. sativa) is used as a medicinal plant overall the world and is known to have anthelmintic activity. Caenorhabditis elegans (C. elegans), a common cost-effective model organism that is easily maintained, is useful to determine the anthelmintic activity of new compounds derived from natural products. In our study we aimed to evaluate through toxicity assays the nematocidal activity of N. sativa on C. elegans during its larval and adult stages. Different concentrations of N. sativa oil (900, 450 and 270 mg/mL) were tested and toxicity assessments were done under stereomicroscope by counting the number of surviving nematodes. This study showed that N. sativa essential oil significantly decreases survival of C. elegans in both larval and adult stages at 900 mg/mL final concentration. Larval-stage worms were more sensitive to N. sativa essential oil than were adults. We recommend further studies on other effects of N. sativa on C. elegans after removing the toxic compound(s) from the extract. The further discovery of N. sativa essential oil compounds responsible for anthelmintic activity and determination of their mechanisms of toxicity can pave the way toward new medicines.en_US
dc.identifier.citationYılmaz, M. (2019). Bibliyometriye Eleştirel Bir Bakış (A Critical View on Bibliometrics). Turk Kutuphaneciligi - Turkish Librarianship, 33(1), 43–49.en_US
dc.identifier.doi10.13189/app.2021.090405en_US
dc.identifier.endpage126en_US
dc.identifier.issn2332-0036en_US
dc.identifier.issn2332-0044en_US
dc.identifier.issue4en_US
dc.identifier.startpage117en_US
dc.identifier.urihttps://doi.org/10.13189/app.2021.090405
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2034
dc.identifier.volume9en_US
dc.identifier.wosWOS:000691592500005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorOlgun, Abdullah
dc.language.isoenen_US
dc.publisherHORIZON RESEARCH PUBLISHINGen_US
dc.relation.ispartofADVANCES IN PHARMACOLOGY AND PHARMACYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNigella Sativaen_US
dc.subjectAnthelminticen_US
dc.subjectCaenorhabditis Elegansen_US
dc.subjectMedicinal Plantsen_US
dc.subjectPhytotherapyen_US
dc.subjectHerbal Medicineen_US
dc.titleAnthelmintic activity of nigella sativa against caenorhabditis elegansen_US
dc.typeArticleen_US

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