Angiotensin IV improves spatial memory in streptozotocin?induced diabetic rats by reducing oxidative stress and altering BDNF levels

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dc.authoridHuri Bulut / 0000-0003-2706-9625en_US
dc.authorscopusidHuri Bulut / 57185264300
dc.authorwosidHuri Bulut / AAM-1432-2020
dc.contributor.authorKılıç, Aysu
dc.contributor.authorÜstunova, Savaş
dc.contributor.authorElibol, Birsen
dc.contributor.authorBulut, Huri
dc.contributor.authorMeral, İsmail
dc.contributor.authorŞahin, Gülderen
dc.date.accessioned2021-07-05T08:08:29Z
dc.date.available2021-07-05T08:08:29Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractIn this study, we investigated the protective effects of angiotensin IV (Ang IV) on cognitive function in streptozotocin (STZ)?induced diabetic rats. Male Wistar albino rats, were randomly divided into four groups; control (C), diabetes (Dia, 60 mg/kg, STZ, i.p.), Ang IV (5 ?g/kg, s.c.) and Dia+Ang IV. The passive avoidance and Morris water maze (MWM) tests were used to evaluate learning and memory performance. Behavioral tests were carried out between 21 and 30 days after the initial Ang IV injection. Hippocampi were dissected and retained for biochemical and Western blot analysis. The Dia group exhibited the poorest behavioral results, while the Dia+Ang IV group performed highest on the MWM task. Superoxide dismutase, glutathione peroxidase, and malondialdehyde levels increased significantly in the Dia group compared to Dia+Ang IV. Brain?derived neurotrophic factor (BDNF) and N?methyl?D?aspartate levels were significantly elevated, while levels of GABAA significantly decreased, in the Dia+Ang IV group compared to the Dia group. These findings suggest that peripheral administration of Ang IV ameliorated spatial memory in diabetic rats by decreasing hippocampal oxidative stress and BDNF levels.en_US
dc.identifier.citationKilic, A., Ustunova, S., Elibol, B., Bulut, H., Meral, I., & Sahin, G. (2021). Angiotensin IV improves spatial memory in streptozotocin‑induced diabetic rats by reducing oxidative stress and altering BDNF levels. Acta neurobiologiae experimentalis, 81(2), 161–170.en_US
dc.identifier.doi10.21307/ane-2021-015en_US
dc.identifier.endpage170en_US
dc.identifier.issue2en_US
dc.identifier.pmid34170263en_US
dc.identifier.scopus2-s2.0-85110403973en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage161en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1871
dc.identifier.urihttps://doi.org/10.21307/ane-2021-015
dc.identifier.volume81en_US
dc.identifier.wosWOS:000665479700005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBulut, Huri
dc.language.isoenen_US
dc.publisherNCI CPTACen_US
dc.relation.ispartofActa Neurobiol Exp (Wars)en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAngiotensin IVen_US
dc.subjectCognitive Functionsen_US
dc.titleAngiotensin IV improves spatial memory in streptozotocin?induced diabetic rats by reducing oxidative stress and altering BDNF levelsen_US
dc.typeArticleen_US

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