The effect of Annona muricata (Graviola) on the prevention of brain damage due to ionizing radiation in rats

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dc.authoridEne, Antoaneta/0000-0002-6976-0767
dc.authoridALMISNED, GHADA/0000-0001-9072-4480
dc.authoridTekin, Huseyin Ozan/0000-0002-0997-3488
dc.authoridZAKALY, Hesham M.H./0000-0002-7645-9964
dc.authorwosidEne, Antoaneta/C-1386-2011
dc.authorwosidALMISNED, GHADA/AIF-4569-2022
dc.authorwosidTekin, Huseyin Ozan/J-9611-2016
dc.authorwosidZAKALY, Hesham M.H./E-8136-2016
dc.contributor.authorElmas, Ozlem
dc.contributor.authorKeskin, Emrah
dc.contributor.authorSahin, Havva Hande Keser
dc.contributor.authorGuven, Berrak
dc.contributor.authorAlmisned, Ghada
dc.contributor.authorZakaly, Hesham M. H.
dc.contributor.authorTekin, H. O.
dc.date.accessioned2024-05-19T14:46:23Z
dc.date.available2024-05-19T14:46:23Z
dc.date.issued2024
dc.departmentİstinye Üniversitesien_US
dc.description.abstractIn this study, it was aimed to evaluate the effect of ethanol extract of Annona Muricata (AM) leaves in the prevention of brain damage caused by ionizing radiation (IR). This study was conducted in the Experimental Animal Research Unit of a university with 28 adults female Wistar Albino rats. The experimental groups were as follows: Control group (n = 8), AM group (n = 6), IR group (n = 8), AM + IR group (n = 6). In the IR group, astrocyte hypertrophy, microglial reaction and inflammatory reaction levels were significantly higher than the control and AM groups (P < 0.001). Edema was significantly higher in the IR group compared to the control group (P=0.001). The MDA of the IR group was significantly higher compared to the control group and AM group (P=0.031, P=0.006, respectively). The MDA of the AM + IR group was significantly higher than the AM group (P=0.039). Our findings show that histomorphology and oxidant damage caused by IR can be ameliorated using AM, as demonstrated by the comparison of the controls to AM + IR recipients, which showed similar histomorphology and oxidant damage levels.en_US
dc.description.sponsorshipPrincess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia [PNURSP2024R149]en_US
dc.description.sponsorshipPrincess Nourah bint Abdulrahman University Researchers Supporting Project number (PNURSP2024R149) , Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.en_US
dc.identifier.doi10.1016/j.heliyon.2024.e25932
dc.identifier.issn2405-8440
dc.identifier.issue4en_US
dc.identifier.pmid38370260en_US
dc.identifier.scopus2-s2.0-85184783748en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org10.1016/j.heliyon.2024.e25932
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5512
dc.identifier.volume10en_US
dc.identifier.wosWOS:001184951500001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherCell Pressen_US
dc.relation.ispartofHeliyonen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectRadiationen_US
dc.subjectIonizingen_US
dc.subjectAnnona Muricataen_US
dc.subjectAcute Brain Injuriesen_US
dc.subjectPreventative Careen_US
dc.titleThe effect of Annona muricata (Graviola) on the prevention of brain damage due to ionizing radiation in ratsen_US
dc.typeArticleen_US

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