The effect of omentectomy on the blood levels of adipokines in obese patients with endometrial cancer

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dc.authoridHuri Bulut / 0000-0003-2706-9625en_US
dc.authorscopusidHuri Bulut / 57185264300en_US
dc.authorwosidHuri Bulut / AAM-1432-2020en_US
dc.contributor.authorComba, Cihan
dc.contributor.authorÖzdemir, İsa Aykut
dc.contributor.authorDemirayak, Gökhan
dc.contributor.authorErdoğan, Şakir Volkan
dc.contributor.authorDemir, Ömer
dc.contributor.authorÖzlem Yıldız, Güneş
dc.contributor.authorBulut, Huri
dc.contributor.authorKarakaş, Sema
dc.contributor.authorGülseren, Varol
dc.contributor.authorAfşar, Selim
dc.contributor.authorGüngördük, Kemal
dc.date.accessioned2022-07-05T14:26:39Z
dc.date.available2022-07-05T14:26:39Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective To investigate the blood levels of adipokines in obese patients with endometrial cancer who have and have not undergone omentectomy. Methods Between September 2017 and September 2019, the study recruited 54 patients with endometrial cancer. Measurements were taken of blood levels of human leptin, perilipin-1, adiponectin, adipolin, resistin, visfatin, and estrone preoperatively and postoperatively before adjuvant therapy or at the end of one month. The serum samples were separated by centrifugation for 10 mins at 3,000 revolutions/min, then stored at ?80 °C until assay. Results In this prospective study, a total of 54 endometrial cancer patients were analyzed in two separate groups according to the omentectomy status. Comprehensive staging surgery with omentectomy and without omentectomy was performed in 26 patients and 28 patients, respectively. The age, body mass index, body fat index, waist circumference, and skin thickness values of the patients with and without omentectomy were found to be similar. No statistically significant difference was determined between the patients with and without omentectomy in respect of the blood level of the adipokines measured preoperatively. A strong statistically significant correlation was determined between the pre and postoperative levels of Human Leptin (p = 0.002), perilipin-1(p = 0.001), adipolin (p < 0.001), adiponectin (p < 0.001), resistin (p = 0.001), visfatin (p < 0.001), and estrone (p = 0.004) (r = ?0.43, ?0.47, 0.75, 0.84, ?0.47, - 0.58, ?0.41, respectively) Conclusions Omentectomy affected the postoperative blood levels of adipokines in obese patients with endometrial cancer. As omentectomy may have some positive effects on metabolism in these patients, it may be considered during endometrial cancer surgery due to the possible positive metabolic effects.en_US
dc.identifier.citationComba, C., Ozdemir, I. A., Demirayak, G., Erdogan, S. V., Demir, O., Özlem Yıldız, G., . . . Gungorduk, K. (2022). The effect of omentectomy on the blood levels of adipokines in obese patients with endometrial cancer. Obesity Research and Clinical Practice, 16(3), 242-248. doi:10.1016/j.orcp.2022.06.002en_US
dc.identifier.doi10.1016/j.orcp.2022.06.002en_US
dc.identifier.endpage248en_US
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85132220540en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage242en_US
dc.identifier.urihttps://doi.org/10.1016/j.orcp.2022.06.002
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2978
dc.identifier.volume16en_US
dc.identifier.wosWOS:000816207800008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBulut, Huri
dc.language.isoenen_US
dc.publisherElsevier Scienceen_US
dc.relation.ispartofObesity Research and Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEndometrial Canceren_US
dc.subjectOmentectomyen_US
dc.subjectLeptinen_US
dc.subjectPerilipin-1en_US
dc.subjectAdipolinen_US
dc.subjectAdiponectinen_US
dc.subjectResistinen_US
dc.subjectVisfatinen_US
dc.titleThe effect of omentectomy on the blood levels of adipokines in obese patients with endometrial canceren_US
dc.typeArticleen_US

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