The endocannabinoid system, a new gatekeeper in the pharmacology of human hepatocellular carcinoma

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dc.authoridBaziyar, Payam/0000-0001-7487-3662
dc.authoridNabavi, Noushin/0000-0002-5471-6229
dc.authorwosidBaziyar, Payam/KHE-3005-2024
dc.contributor.authorEbrahimi, Nasim
dc.contributor.authorFar, Nazanin Pazhouhesh
dc.contributor.authorFakhr, Siavash Seifollahy
dc.contributor.authorFaghihkhorasani, Ferdos
dc.contributor.authorMiraghel, Seyed Ali
dc.contributor.authorChaleshtori, Siavash Rahimian
dc.contributor.authorRezaei-Tazangi, Fatemeh
dc.date.accessioned2024-05-19T14:41:15Z
dc.date.available2024-05-19T14:41:15Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractDespite numerous prevention methodologies and treatment options, hepatocellular carcinoma (HCC) still remains as the third leading life-threatening cancer. It is thus pertinent to develop new treatment modality to fight this devastating carcinoma. Ample recent studies have shown the anti-inflammatory and antitumor roles of the endocannabinoid system in various forms of cancers. Preclinical studies have also confirmed that cannabinoid therapy can be an optimal regimen for cancer treatments. The endocannabinoid system is involved in many cancer-related processes, including induction of endoplasmic reticulum (ER) stress-dependent apoptosis, autophagy, PITRK and ERK signaling pathways, cell invasion, epithelial-mesenchymal transition (EMT), and cancer stem cell (CSC) phenotypes. Moreover, changes in signaling transduction of the endocannabinoid system can be a potential diagnostic and prognostic biomarker for HCC. Due to its pivotal role in lipid metabolism, the endocannabinoid system affects metabolic reprogramming as well as lipid content of exosomes. In addition, due to the importance of non-coding RNAs (ncRNAs), several studies have examined the relationship between microRNAs and the endocannabinoid system in HCC. However, HCC is a pathological condition with high heterogeneity, and therefore using the endocannabinoid system for treatment has faced many controversies. While some studies favored a role of the endocannabinoid system in carcinogenesis and tumor induction, others exhibited the anticancer potential of endocannabinoids in HCC. In this review, specific studies delineating the relationship between endocannabinoids and HCC are examined. Based on collected findings, detailed studies of the molecular mechanism of endocannabinoids as well as preclinical studies for investigating therapeutic or carcinogenic impacts in HCC cancer are strongly suggested.en_US
dc.identifier.doi10.1016/j.envres.2023.115914
dc.identifier.issn0013-9351
dc.identifier.issn1096-0953
dc.identifier.pmid37062475en_US
dc.identifier.scopus2-s2.0-85153969520en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org10.1016/j.envres.2023.115914
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5083
dc.identifier.volume228en_US
dc.identifier.wosWOS:000998662600001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.relation.ispartofEnvironmental Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectEndocannabinoidsen_US
dc.subjectCancer Stem Cellsen_US
dc.subjectEndoplasmic Reticulum (Er) Stressen_US
dc.subjectApoptosisen_US
dc.subjectTumorigenesisen_US
dc.subjectNovel Cancer Therapyen_US
dc.subjectNanoparticlesen_US
dc.titleThe endocannabinoid system, a new gatekeeper in the pharmacology of human hepatocellular carcinomaen_US
dc.typeReview Articleen_US

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