Interactions between ticks and lyme disease spirochetes

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dc.authoridÖzlem Büyüktanır Yaş / 0000-0002-7641-7350en_US
dc.authorscopusidÖzlem Büyüktanır Yaş / 57221162761
dc.authorwosidÖzlem Büyüktanır Yaş / AAP-2720-2020
dc.contributor.authorPal, Utpal
dc.contributor.authorKitsou, Chrysoula
dc.contributor.authorDrecktrah, Dan
dc.contributor.authorBüyüktanır Yaş, Özlem
dc.contributor.authorFikrig, Erol
dc.date.accessioned2020-12-17T08:00:19Z
dc.date.available2020-12-17T08:00:19Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionPubMed Yayın Yılı: 2020
dc.description.abstractBorrelia burgdorferi sensu lato causes Lyme borreliosis in a variety of animals and humans. These atypical bacterial pathogens are maintained in a complex enzootic life cycle that primarily involves a vertebrate host and Ixodes spp. ticks. In the Northeastern United States, I. scapularis is the main vector, while wild rodents serve as the mammalian reservoir host. As B. burgdorferi is transmitted only by I. scapularis and closely related ticks, the spirochete-tick interactions are thought to be highly specific. Various borrelial and arthropod proteins that directly or indirectly contribute to the natural cycle of B. burgdorferi infection have been identified. Discrete molecular interactions between spirochetes and tick components also have been discovered, which often play critical roles in pathogen persistence and transmission by the arthropod vector. This review will focus on the past discoveries and future challenges that are relevant to our understanding of the molecular interactions between B. burgdorferi and Ixodes ticks. This information will not only impact scientific advancements in the research of tick- transmitted infections but will also contribute to the development of novel preventive measures that interfere with the B. burgdorferi life cycle.en_US
dc.identifier.citationPal, U., Kitsou, C., Drecktrah, D., Yaş, Ö. B., & Fikrig, E. (2020). Interactions Between Ticks and Lyme Disease Spirochetes. Current issues in molecular biology, 42, 113–144. Advance online publication. https://doi.org/10.21775/cimb.042.113en_US
dc.identifier.doi10.21775/cimb.042.113en_US
dc.identifier.endpage144en_US
dc.identifier.issn1467-3045en_US
dc.identifier.pmid33289683en_US
dc.identifier.scopus2-s2.0-85098445477en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage113en_US
dc.identifier.urihttps://doi.org/10.21775/cimb.042.113
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1281
dc.identifier.wosWOS:000600423600003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBüyüktanır Yaş, Özlem
dc.language.isoenen_US
dc.publisherCaister Academic Pressen_US
dc.relation.ispartofCurrent issues in molecular biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleInteractions between ticks and lyme disease spirochetesen_US
dc.typeArticleen_US

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