Oxidative stress and antioxidant status in threatened preterm labor

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dc.authoridÖzel, Aysegül/0000-0002-0283-1049
dc.authoridHamzaoğlu Canbolat, Kübra/0000-0002-7965-8301
dc.authoridKaymak, Didem/0000-0002-2755-1932
dc.authoridMadazli, Riza/0000-0002-6400-1964
dc.authorwosidÖzel, Aysegül/ABL-8427-2022
dc.authorwosidHamzaoğlu Canbolat, Kübra/AAO-4949-2020
dc.authorwosidKaymak, Didem/AAA-8749-2020
dc.authorwosidMadazli, Riza/AAD-3721-2021
dc.contributor.authorCanbolat, Kubra Hamzaoglu
dc.contributor.authorOncul, Mahmut
dc.contributor.authorOzel, Aysegul
dc.contributor.authorDavutoglu, Ebru Alici
dc.contributor.authorKaymak, Didem
dc.contributor.authorBulut, Huri
dc.contributor.authorMadazli, Riza
dc.date.accessioned2024-05-19T14:47:03Z
dc.date.available2024-05-19T14:47:03Z
dc.date.issued2024
dc.departmentİstinye Üniversitesien_US
dc.description.abstractPurposeThe purpose of this study was the evaluation of total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI) and superoxide dismutase (SOD) levels in women with threatened preterm labor (TPL) and also to compare the levels of these oxidative stress biomarkers of TPL pregnancies that had preterm and term deliveries.MethodsThis case-control study was conducted on 46 patients diagnosed with TPL and 47 healthy pregnant women matched for gestational age. Patients with threatened preterm labor were divided into two groups: true preterm birth (TPB) group (n = 16) and false preterm birth (FPB) group (n = 30) groups. Maternal serum SOD, TOS and TAS levels were measured by a spectrophotometric method using a commertial kit. OSI level for each patient was calculated by using the formula: (TOS (mu mol center dot H2O2 center dot equiv/L) x 100)/(TAS (mu mol center dot Trolox center dot equiv/L)).ResultsThe mean TAS levels of the TPB and FPB groups were significantly lower than those of the control group (0.96 +/- 0.3 vs 1.36 +/- 0.34, p1 < 0.001; 0.97 +/- 0.22 vs 1.36 +/- 0.34, p2 < 0.001, respectively). The mean SOD, TOS and OSI levels of the TPB and FPB groups were significantly higher than those of the control group (p < 0.001). There was no significant difference between the TPB and FPB groups for any oxidative stress biomarkers.ConclusionThe maternal serum oxidative stress biomarkers are increased in pregnancies with TPL. However, these are not effective in predicting preterm birth in pregnancies with TPL.en_US
dc.identifier.doi10.1007/s00404-023-07023-7
dc.identifier.endpage1400en_US
dc.identifier.issn0932-0067
dc.identifier.issn1432-0711
dc.identifier.issue4en_US
dc.identifier.pmid37004538en_US
dc.identifier.scopus2-s2.0-85152023594en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1395en_US
dc.identifier.urihttps://doi.org10.1007/s00404-023-07023-7
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5644
dc.identifier.volume309en_US
dc.identifier.wosWOS:000961734700001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofArchives of Gynecology and Obstetricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectTotal Antioxidant Statusen_US
dc.subjectTotal Oxidant Statusen_US
dc.subjectOxidative Stress Indexen_US
dc.subjectSuperoxide Dismutaseen_US
dc.subjectPreterm Laboren_US
dc.titleOxidative stress and antioxidant status in threatened preterm laboren_US
dc.typeArticleen_US

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