The Influence of Human Leukocyte Antigens in Graft Versus Host Disease and Survival After Hematopoietic Stem Cell Transplantation in Pediatric Patients with Leukemia

Yükleniyor...
Küçük Resim

Tarih

2021

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

GALENOS YAYINCILIK

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

Objective: Hematopoietic stem cell transplantation (HSCT) is an important therapy for hematological diseases. One of the most significant complications of HSCT is graft versus host disease (GVHD), and major histocompatibility complex (MHC) is well known to affect GVHD and graft rejection. This study aimed to examine the effect of human leukocyte antigens (HLA) on the incidence of GVHD development in patients with leukemia. Methods: The association between HLA and GVHD formation was evaluated in 57 patients with HSCT with HLA-identical sibling donors, of whom 37 were boys and 20 were girls with a mean age of 10.11 years. All patients were diagnosed with leukemia; acute myeloid leukemia (n=33), acute lymphoblastic leukemia (n=15), and chronic myeloid leukemia (n=9). Transplantation pairs were worked for HLA-A,-B,-C, and-DRB1 alleles. Class I HLA antigens were investigated using Terasaki microlymphocytotoxicity, whereas class II HLA alleles with polymerase chain reaction -sequence-specific amplification method. Results: The frequency of developing GVHD in patients with HSCT was found to be 17.5% (n=10). HLA-DRB1*04 allelic frequency [p=0.024, odds ratio (OR): 4.87] was found to be higher in patients who developed GVHD. However, the HLA-DRB1*11 allelic frequency (p=0.031, OR: 0.12) was lower in patients who developed GVHD compared to patients who did not develop GVHD. Furthermore, HLA-B38 (p=0.002) and HLA-B41 (p=0.002) antigens were found only in patients who developed GVHD. The frequencies of the HLA-A26 allele (p=0.12) and the HLADRB1*11 allele (p=0.037, OR: 4.0) were higher in patients with relapse after HSCT; however, the frequencies of the HLA-A2 allele (p=0.033, OR: 0.19) was lower in patients who relapsed after HSCT. Conclusion: This study assessed the relationship of HLA class with GVHD, relapse, and survival in children after HSCT in pediatric patients with leukemia.

Açıklama

Anahtar Kelimeler

GVHD, Leukemia, HSCT, HLA CLASS-I, Marrow Transplantation, Association, Donor, Risk

Kaynak

MEDICAL JOURNAL OF BAKIRKOY

WoS Q Değeri

N/A

Scopus Q Değeri

Q4

Cilt

17

Sayı

4

Künye

Özdilli, K., Oğuz, F. S., Anak, S., Öğret, Y., Çiftçi, H. Ş., Oğuz, R., & Carin, M. (2021). The Influence of Human Leukocyte Antigens in Graft Versus Host Disease and Survival After Hematopoietic Stem Cell Transplantation in Pediatric Patients with Leukemia. Med J Bakirkoy, 17, 280-285.