Lichens exerts an anti-proliferative effect on human breast and lung cancer cells through induction of apoptosis

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dc.authoridEngin Ulukaya / 0000-0003-4875-5472
dc.authoridMerve Erkısa Genel / 0000-0002-3127-742X
dc.authorscopusidEngin Ulukaya / 6602927353
dc.authorscopusidMerve Erkısa Genel / 57126208900
dc.authorwosidEngin Ulukaya / K-5792-2018
dc.authorwosidMerve Erkısa Genel / AAM-1001-2020
dc.contributor.authorÖztürk, Şule
dc.contributor.authorErkısa Genel, Merve
dc.contributor.authorOran, Oran
dc.contributor.authorUlukaya, Engin
dc.contributor.authorÇelikler, Serap
dc.contributor.authorArı, Ferda
dc.date.accessioned2020-08-30T20:01:36Z
dc.date.available2020-08-30T20:01:36Z
dc.date.issued2021
dc.departmentİstinye Üniversitesi, Rektörlüken_US
dc.description.abstractSuccessful cancer treatment still requires new complexes or compounds from natural sources. Therefore, we investigated anti-growth/apoptotic effects of methanol extracts of the lichen species (Xanthoparmelia somloensis (Gleyn.) Hale, Usnea intermedia (A. Massal.) Jatta, Bryoria capillaris (Ach.) Brodo & D. Hawksw and Lobaria pulmonaria (L.) Hoffm.) on human lung (A549, H1299) and breast (MCF-7, MDA-MB-231) cancer cell lines. Anti-growth effects were monitored by the MTT and ATP viability assays. Cell death mode was evaluated by employing the fluorescence staining of nucleus, caspase-cleaved cytokeratin 18 detection, caspase 3/7 activity assay, Anneksin V cytofluorimetric assay and mitochondria membrane potential assay. Among the lichen extracts, Usnea intermedia exhibited strong anti-growth activity in a dose-dependent manner (1.56–100 µg/ml) compared to the others. Usnea intermedia was especially cytotoxic against MDA-MB-231 and H1299 cells (IC 50 value for was found 3.0 and 10.2 ?g/ml respectively). The cytotoxicity was resulted from apoptosis as proved by the presence of pyknotic nuclei, caspase 3/7 activity, phosphatidylserine translocation and loss of mitochondria membrane potential. In conclusion, Usnea intermedia warrants for further in vivo evaluation as a new alternative in cancer treatment. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.en_US
dc.identifier.citationOzturk, S., Erkisa, M., Oran, S., Ulukaya, E., Celikler, S., & Ari, F. (2019). Lichens exerts an anti-proliferative effect on human breast and lung cancer cells through induction of apoptosis. Drug and chemical toxicology, 1-9.en_US
dc.identifier.doi10.1080/01480545.2019.1573825en_US
dc.identifier.issn0148-0545en_US
dc.identifier.pmid30835567en_US
dc.identifier.scopus2-s2.0-85062569279en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1080/01480545.2019.1573825
dc.identifier.urihttps://hdl.handle.net/20.500.12713/317
dc.identifier.wosWOS:000627598500004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorErkısa Genel, Merveen_US
dc.institutionauthorUlukaya, Enginen_US
dc.language.isoenen_US
dc.publisherTaylor and Francis Ltden_US
dc.relation.ispartofDrug and Chemical Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptosisen_US
dc.subjectCancer Cell Deathen_US
dc.subjectCytotoxicityen_US
dc.subjectLichensen_US
dc.subjectUsnea Intermediaen_US
dc.titleLichens exerts an anti-proliferative effect on human breast and lung cancer cells through induction of apoptosisen_US
dc.typeArticleen_US

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