Hyperthermia alters neurobehavior by affecting cell proliferation and neuronal survival in young male rats

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dc.authoridEyuboglu, Signem/0000-0002-0253-2217
dc.authoridYilmaz, Bayram/0000-0002-2674-6535
dc.authoridKilic, Ertugrul/0000-0001-6494-8923
dc.authorwosidEyuboglu, Signem/AAW-1273-2020
dc.authorwosidYilmaz, Bayram/IXD-3395-2023
dc.contributor.authorMete, Fatih
dc.contributor.authorEyuboglu, Signem
dc.contributor.authorVitrinel, Ayca
dc.contributor.authorKilic, Ulkan
dc.contributor.authorErdogan, Cihan Suleyman
dc.contributor.authorKilic, Ertugrul
dc.contributor.authorYilmaz, Bayram
dc.date.accessioned2024-05-19T14:39:06Z
dc.date.available2024-05-19T14:39:06Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractMaintenance of body temperature within physiological range is critical for the fetal and neonatal development. Hyperthermia is one of the most frequently encountered pediatric complaints and may cause neurological disorders due to neuronal injury. In this study, we aimed to investigate the effects of hyperthermia on behavioral alterations, neuronal survival, apoptosis, and cell proliferation in young male Sprague-Dawley rats. Twenty-one 13-day-old rats were randomly divided into three groups (n = 7 per group). Body temperature was increased to 39 degrees C and 41 degrees C in a hyperthermia induction chamber for 30 min, whereas the animals in control group were maintained at 36 degrees C. Twenty-four hours after hyperthermia, animals were subjected to the open field test, elevated-O-maze test, and grip strength test to assess the locomotor activity, anxiety, and motor function. Neuronal survival, apoptosis, and cell proliferation were investigated in cortex, hippocampal dentate gyrus (DG) and CA1 regions, and corpus callosum (CC). Decreased locomotor activity and motor function and increased anxiety were observed in the hyperthermia groups, and these were more pronounced in the 41 degrees C group. Neuronal survival was significantly decreased in DG, CA1, and CC in the hyperthermia groups (**p < 0.01). Apoptosis was significantly induced in cortex, DG, and CC of the animals exposed to heat (*p < 0.05). In addition, cell proliferation positivity decreased significantly only in DG and CC of the animals exposed to heat (*p < 0.05). Our results suggest that neurobehavioral deficits caused by hyperthermia may be due to the increased apoptosis and neuronal cell death and decreased cell proliferation in the brain of postnatal developing rats.en_US
dc.identifier.doi10.1002/jdn.10258
dc.identifier.endpage319en_US
dc.identifier.issn0736-5748
dc.identifier.issn1873-474X
dc.identifier.issue3en_US
dc.identifier.pmid37029601en_US
dc.identifier.scopus2-s2.0-85152299882en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage307en_US
dc.identifier.urihttps://doi.org10.1002/jdn.10258
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4699
dc.identifier.volume83en_US
dc.identifier.wosWOS:000963494500001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofInternational Journal of Developmental Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectAnxietyen_US
dc.subjectCell Proliferationen_US
dc.subjectHyperthermiaen_US
dc.subjectLocomotor Activityen_US
dc.subjectMotor Functionen_US
dc.titleHyperthermia alters neurobehavior by affecting cell proliferation and neuronal survival in young male ratsen_US
dc.typeArticleen_US

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