Is it possible that we can increase the lymph node number in cases with rectum tumor receiving neoadjuvant therapy?

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dc.contributor.authorErhan, Selma Sengiz
dc.contributor.authorKeser, Sevinc Hallac
dc.contributor.authorKamali, Gulcin Harman
dc.contributor.authorSensu, Sibel
dc.contributor.authorDincer, Selvi
dc.contributor.authorSaglam, Fazil
dc.date.accessioned2024-05-19T14:38:56Z
dc.date.available2024-05-19T14:38:56Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractBackground: Though the recommended sampled lymph node number in colorectal carcinomas is at least 12, due to shrinkage after preoperative neoadjuvant chemoradiotherapy (NCRT), it can be difficult to attain that number. Aim: Our aim is to increase the lymph node number by applying alcohol fixation on the formalin-fixed resection materials of the patients that received or not received neoadjuvant therapy and to evaluate the changes in staging due to obtained lymph nodes. Settings and Design: Non-randomized controlled trial. Materials and Methods: Lymph node dissection was performed in the resection materials with rectum tumor which were formalin- and afterwards, alcohol-fixed. The number of lymph nodes obtained by both of the methods and status of metastasis were evaluated statistically. Results: Of the total 76 rectal tumors, 57 had and 19 had not received NCRT. The number of lymph node was adequate in 89.5% cases with no NCRT and in 63.2% cases with NCRT. While no change was observed after the alcohol fixation in the cases fulfilling adequacy criterion among those with no NCRT (p = 1.000), the adequacy rate increased from 63.2% to 87.7% in those with NCRT (p < 0.001). Although statistically insignificant, there was a change in pN stage in eight cases. In three of them, the stage varied from pN0 to pN1c, and in five cases, from pN1a to pN1b. Conclusion: Using solutions as alcohol during fixation might facilitate the identification of metastatic lymph nodes, might change the stage of the disease and therefore, might affect the patient-based therapy.en_US
dc.identifier.doi10.4103/ijpm.ijpm_1230_21
dc.identifier.endpage785en_US
dc.identifier.issn0377-4929
dc.identifier.issn0974-5130
dc.identifier.issue4en_US
dc.identifier.pmid38084532en_US
dc.identifier.scopus2-s2.0-85179638905en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage780en_US
dc.identifier.urihttps://doi.org10.4103/ijpm.ijpm_1230_21
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4654
dc.identifier.volume66en_US
dc.identifier.wosWOS:001146777400014en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofIndian Journal of Pathology and Microbiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectAlcohol Fixationen_US
dc.subjectLymph Nodeen_US
dc.subjectNeoadjuvant Chemoradiotherapyen_US
dc.subjectRectumen_US
dc.titleIs it possible that we can increase the lymph node number in cases with rectum tumor receiving neoadjuvant therapy?en_US
dc.typeArticleen_US

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