Peritoneal metastasis of advanced epithelial ovarian carcinoma treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: A retrospective international multicentric data analysis

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dc.authoridArjona-Sanchez, Alvaro/0000-0002-3024-3009
dc.authoridKepenekian, Vahan/0000-0001-9885-8600
dc.authoridIREZ, TULAY/0000-0001-8272-4931
dc.authoridJOHN, SPILIOTIS/0000-0002-7942-4126
dc.authoridGlehen, Olivier/0000-0002-2802-4974
dc.authoridBarat, Shoma/0000-0002-8879-4276
dc.authoridMorris, David Lawson/0000-0001-9377-8521
dc.authorwosidSommariva, Antonio/IAM-5888-2023
dc.authorwosidArjona-Sanchez, Alvaro/I-6730-2019
dc.authorwosidKepenekian, Vahan/AFF-8361-2022
dc.authorwosidIREZ, TULAY/B-6089-2014
dc.contributor.authorTorun, Bahar Canbay
dc.contributor.authorGlehen, Olivier
dc.contributor.authorKepenekian, Vahan
dc.contributor.authorSardi, Armando
dc.contributor.authorArjona-Sanchez, Alvaro
dc.contributor.authorYonemura, Yutaka
dc.contributor.authorBarat, Shoma
dc.date.accessioned2024-05-19T14:38:53Z
dc.date.available2024-05-19T14:38:53Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractIntroduction: The purpose of our study was to evaluate outcome data after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with peritoneal metastasis originating from advanced epithelial ovarian carcinoma (PMOC). Patients and methods: A retrospective international multi-institutional registry was established through collaborative efforts of participating units affiliated with the Peritoneal Surface Oncology Group. Results: One thousand four hundred and ninety-one patients from 11 specialized units underwent CRS and HIPEC that of those 326 (21.9%) upfront surgeries, 504 (33.8%) interval surgery, and 661(44.3%) recurrent cases. Complete Cytoreduction(CC0/1) was achieved in 1213 patients (81.3%). Treatment -related mortality was 0.8%, major operative complications (Grades 3-5) was 25.1%. Factors associated with major operative complications include prior surgical score (PSS for recurrent cases; RC) PSS>2,p = 0.000), PCI(<= 15, >15 cut-off level; p <= 0.000), completeness of cytoreduction (CC, p=0.000), high CA125 levels (>25 mg/dl), presence of ascites, high CRP (>5 mg/dl) levels and low albumin levels (below to 2.5 mg/dl) (p <= 0.05). The median survival was 58 months in upfront surgery(UFS), 60 months in interval surgery(IS), and 42 months in RC. The overall survival for five years was 45% for UFS, 37% for IS, 28% for RC cases. CCscore (p = 0.000), CA125, CRP and albumin levels (p <= 0.05) were predictors for progression free survival. PCI(p <= 0.000), major postoperative complications (p = 0.004), incomplete CRS(CC2/3)(p < 0.001), prior chemotherapy (hazard ratio [HR], 3-8; p < 0.001) and PSS>2 for RC were independent predictors of poor overall survival. Conclusion: The combined treatment strategy for PMOC may be performed safely with acceptable morbidity and mortality in the specialized units. (c) 2023 Elsevier Ltd, BASO The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.en_US
dc.identifier.doi10.1016/j.ejso.2023.03.214
dc.identifier.endpage1494en_US
dc.identifier.issn0748-7983
dc.identifier.issn1532-2157
dc.identifier.issue8en_US
dc.identifier.pmid37085403en_US
dc.identifier.scopus2-s2.0-85152944314en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1489en_US
dc.identifier.urihttps://doi.org10.1016/j.ejso.2023.03.214
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4639
dc.identifier.volume49en_US
dc.identifier.wosWOS:001062794300001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofEjsoen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectAdvanced Epithelial Ovarian Carcinomaen_US
dc.subjectPeritoneal Metastasisen_US
dc.subjectHipecen_US
dc.subjectCytoreductive Surgeryen_US
dc.titlePeritoneal metastasis of advanced epithelial ovarian carcinoma treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: A retrospective international multicentric data analysisen_US
dc.typeArticleen_US

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