Folic acid-conjugated cationic Ag2S quantum dots for optical imaging and selective doxorubicin delivery to HeLa cells

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dc.authoridEngin Ulukaya / 0000-0003-4875-5472en_US
dc.authorscopusidEngin Ulukaya / 6602927353
dc.authorwosidEngin Ulukaya / K-5792-2018
dc.contributor.authorDuman, Fatma Demir
dc.contributor.authorErkısa, Merve
dc.contributor.authorKhodadust, Rouhullah
dc.contributor.authorArı, Ferda
dc.contributor.authorUlukaya, Engin
dc.contributor.authorAcar, Havva Yağcı
dc.date.accessioned2020-08-30T20:08:03Z
dc.date.available2020-08-30T20:08:03Z
dc.date.issued2017
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractWe aim to develop folic acid ( FA)-conjugated cationic Ag2S near-infrared quantum dots (NIRQDs) for the delivery of doxorubicin (DOX) selectively to folate receptor (FR)-positive cancer cells to achieve enhanced drug efficacy and optical tracking in the NIR region. Materials & methods: Cationic Ag2S NIRQDs were decorated with FA using a PEG bridge and loaded with DOX. In vitro studies were performed on FR-positive human cervical carcinoma cells and FR-negative A549 cells. Results: Significantly higher uptake of DOX by human cervical carcinoma cells cells and a greater therapeutic effect along with a strong intracellular optical signal were obtained with DOX-loaded FA-conjugated Ag2S NIRQDs. Conclusion: These Ag2S NIRQDs are promising theranostic nanoparticles for receptor-mediated delivery of DOX with enhanced drug efficacy combined with optical imaging.en_US
dc.description.sponsorshipScientific and Technological Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [113Z164]; Uludag UniversityUludag University [BUAP(F)-2014/3]en_US
dc.description.sponsorshipThis work was financially sponsored by Scientific and Technological Research Council of Turkey (grant number 113Z164) and Uludag University (project BUAP(F)-2014/3). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.en_US
dc.identifier.citationDuman, F. D., Erkisa, M., Khodadust, R., Ari, F., Ulukaya, E., & Acar, H. Y. (2017). Folic acid-conjugated cationic Ag2S quantum dots for optical imaging and selective doxorubicin delivery to HeLa cells. Nanomedicine, 12(19), 2319–2333. https://doi.org/10.2217/nnm-2017-0180en_US
dc.identifier.doi10.2217/nnm-2017-0180en_US
dc.identifier.endpage2333en_US
dc.identifier.issn1743-5889en_US
dc.identifier.issn1748-6963en_US
dc.identifier.issue19en_US
dc.identifier.pmid28875744en_US
dc.identifier.scopus2-s2.0-85030166267en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2319en_US
dc.identifier.urihttps://doi.org/10.2217/nnm-2017-0180
dc.identifier.urihttps://hdl.handle.net/20.500.12713/875
dc.identifier.volume12en_US
dc.identifier.wosWOS:000411843400004en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorUlukaya, Enginen_US
dc.language.isoenen_US
dc.publisherFuture Medicine Ltden_US
dc.relation.ispartofNanomedicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAg2s Quantum Dotsen_US
dc.subjectCancer Therapyen_US
dc.subjectDoxorubicinen_US
dc.subjectNear-Infrared Imagingen_US
dc.subjectTargetingen_US
dc.titleFolic acid-conjugated cationic Ag2S quantum dots for optical imaging and selective doxorubicin delivery to HeLa cellsen_US
dc.typeArticleen_US

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