Controlled release profile of 5-fluorouracil loaded P(AAM-co-NVP-co-DEAEMA) microgel prepared via free radical precipitation polymerization

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dc.authoridAyça Bal Öztürk / 0000-0002-6502-528Xen_US
dc.authorscopusidAyça Bal Öztürk / 57062000100
dc.authorwosidAyça Bal Öztürk / M-4472-2018
dc.contributor.authorÖzbaş, Zehra
dc.contributor.authorÖzkahraman, Bengi
dc.contributor.authorBal Öztürk, Ayça
dc.date.accessioned2020-08-30T20:07:29Z
dc.date.available2020-08-30T20:07:29Z
dc.date.issued2018
dc.departmentİstinye Üniversitesi, Eczacılık Fakültesi, Eczacılık Temel Bilimleri Bölümüen_US
dc.description.abstractA new microgel was prepared by free radical precipitation polymerization of acrylamide (AAM), 1-vinyl-2-pyrrolidone (NVP) and 2-(diethylamino)ethyl methacrylate (DEAEMA) to be used for the controlled drug release. The zeta-potential and particle size of P(AAM-co-NVP-co-DEAEMA) microgel were measured by dynamic light scattering (DLS) measurements and found to be around - 36.4 +/- 6.29 mV and 592 nm, respectively. P(AAM-co-NVP-co-DEAEMA) microgel was loaded with 5-Fluorouracil (5-Fu) as a model drug. In vitro drug release profiles demonstrated that 5-Fu release from P(AAM-co-NVP-co-DEAEMA) microgel at pH 7.4 was much faster than at pH 5.5 and pH 2.1. In addition, release kinetic studies showed that P(AAM-co-NVP-co-DEAEMA) microgel fit into Higuchi model release. The cytotoxicity study indicated that P(AAM-co-NVP-co-DEAEMA) microgel did not exhibit apparent cytotoxicity against L929 cell line. When all of the results were evaluated, it can be seen that P(AAM-co-NVP-co-DEAEMA) microgel can be effectively used as a polymeric drug carrier for the potential drug delivery systems in medical applications.en_US
dc.description.sponsorshipResearch Fund of the Hitit University [MUH19002.14.004]en_US
dc.description.sponsorshipThe authors wish to thank Prof. Dr. Gamze Guclu, Assoc. Prof. Dr. Isil Acar and Assoc. Prof. Dr. Serkan Emik for their support. The present work was financially supported by the Research Fund of the Hitit University, Project no. MUH19002.14.004.en_US
dc.identifier.citationÖzbaş, Z., Özkahraman, B., & Öztürk, A. B. (2018). Controlled release profile of 5-fluorouracil loaded P (AAM-co-NVP-co-DEAEMA) microgel prepared via free radical precipitation polymerization. Polymer Bulletin, 75(7), 3053-3067.en_US
dc.identifier.doi10.1007/s00289-017-2202-0en_US
dc.identifier.endpage3067en_US
dc.identifier.issn0170-0839en_US
dc.identifier.issn1436-2449en_US
dc.identifier.issue7en_US
dc.identifier.scopus2-s2.0-85030554206en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage3053en_US
dc.identifier.urihttps://doi.org/10.1007/s00289-017-2202-0
dc.identifier.urihttps://hdl.handle.net/20.500.12713/774
dc.identifier.volume75en_US
dc.identifier.wosWOS:000434836900019en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorBal Öztürk, Ayçaen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPolymer Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject2-(Diethylamino) Ethyl Methacrylateen_US
dc.subjectMicrogelen_US
dc.subjectPrecipitation Polymerizationen_US
dc.subjectControlled Releaseen_US
dc.subject5-Fluorouracilen_US
dc.titleControlled release profile of 5-fluorouracil loaded P(AAM-co-NVP-co-DEAEMA) microgel prepared via free radical precipitation polymerizationen_US
dc.typeArticleen_US

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