Mixed ligand complexes of Co(II), Ni(II) and Cu(II) with quercetin and diimine ligands: synthesis, characterization, anti-cancer and anti-oxidant activity

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dc.authoridEngin Ulukaya / 0000-0003-4875-5472
dc.authoridMerve Erkısa Genel / 0000-0002-3127-742X
dc.authorscopusidEngin Ulukaya / 6602927353
dc.authorscopusidMerve Erkısa Genel / 57126208900
dc.authorwosidEngin Ulukaya / K-5792-2018
dc.authorwosidMerve Erkısa Genel / AAM-1001-2020
dc.contributor.authorGençkal, Hasene
dc.contributor.authorErkısa Genel, Merve
dc.contributor.authorAlper, Pınar
dc.contributor.authorŞahin, Saliha
dc.contributor.authorUlukaya, Engin
dc.contributor.authorArı, Ferda
dc.date.accessioned2020-08-30T20:06:16Z
dc.date.available2020-08-30T20:06:16Z
dc.date.issued2020
dc.departmentİstinye Üniversitesi, Rektörlüken_US
dc.description.abstractIn this work, mixed ligand complexes of Co(II) Ni(II) and Cu(II) were synthesized using quercetin and diimine (1,10-phenanthroline or 2,2 '-bipyiridine) ligands. The obtained Ni(II) and Co(II) complexes are new and the Cu(II) complexes are synthesized by different method from the literature. The characterization of complexes was performed by elemental analysis, thermogravimetric analysis, ESI-MS, UV-visible and infrared spectral analyses, magnetic susceptibility and molar conductivity measurements. It was found that quercetin, diimine and metal(II) ion form 1:1:1 complexes. Resulting data supported octahedral geometry for Ni(II) and Co(II) complexes and square pyramidal geometry for Cu(II) complexes. The proposed compositions are [Co(queH-1)Cl(phen)(H2O)]center dot 2H(2)O (1, queH = quercetin, phen = 1,10-phenanthroline), [Ni(queH-1)Cl(phen)(H2O)]center dot 2H(2)O (2), [Cu(queH-1)Cl(phen)]center dot 2.5H(2)O (3) and [Cu(queH-1)Cl(bpy)]center dot 2H(2)O (4, bpy = 2,2 '-bipyiridine). Antioxidant capacity and total phenolic content of complexes measured by Folin-Ciocalteu and ABTS methods. Anti-cancer effect of these compounds were tested against different cancer cells (A549, PC-3, HeLa and MCF-7). Apoptosis identified by the fluorescence imaging, caspase cleaved cytokeratin-18 and flow cytometry analysis (annexin V, caspase 3/7, mitochondria membrane potential and oxidative stress). As a result, Cu(II) complexes are more effective than the other compounds and Complex 3 is a promising anti-cancer compound against breast cancer MCF-7 and MDA-MB-231 cells (IC50 values are 2.4 and 5.4 mu M for 48 h, respectively). Flow cytometry analysis exhibited that Complex 3 caused apoptosis in MCF-7 cells. These results support that Complex 3 has anticancer activity and can be a potential anticancer agent especially in breast cancer.en_US
dc.identifier.citationGençkal, H. M., Erkisa, M., Alper, P., Sahin, S., Ulukaya, E., & Ari, F. (2020). Mixed ligand complexes of Co (II), Ni (II) and Cu (II) with quercetin and diimine ligands: synthesis, characterization, anti-cancer and anti-oxidant activity. JBIC Journal of Biological Inorganic Chemistry, 25(1), 161-177.en_US
dc.identifier.doi10.1007/s00775-019-01749-zen_US
dc.identifier.endpage177en_US
dc.identifier.issn0949-8257en_US
dc.identifier.issn1432-1327en_US
dc.identifier.issue1en_US
dc.identifier.pmid31832781en_US
dc.identifier.scopus2-s2.0-85076348979en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage161en_US
dc.identifier.urihttps://doi.org/10.1007/s00775-019-01749-z
dc.identifier.urihttps://hdl.handle.net/20.500.12713/451
dc.identifier.volume25en_US
dc.identifier.wosWOS:000519936700015en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorErkısa Genel, Merveen_US
dc.institutionauthorUlukaya, Enginen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Biological Inorganic Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFlavonoid Complexesen_US
dc.subjectQuercetinen_US
dc.subject1,10-Phenanthrolineen_US
dc.subject2,2 '-Bipyridineen_US
dc.subjectCytotoxicityen_US
dc.subjectAnti-Cancer Activityen_US
dc.subjectAntioxidant Activityen_US
dc.titleMixed ligand complexes of Co(II), Ni(II) and Cu(II) with quercetin and diimine ligands: synthesis, characterization, anti-cancer and anti-oxidant activityen_US
dc.typeArticleen_US

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