Tandem high-dose chemotherapy followed by autologous stem cell transplantation: An infant with trilateral retinoblastoma

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dc.authoridKebudi, Rejin/0000-0003-4344-8174
dc.authoridOztunali, Cigdem/0000-0003-0451-9400
dc.authoridOzdemir, Zeynep Canan/0000-0002-9172-9627
dc.authoridZengin Ersoy, Gizem/0000-0002-8968-9849
dc.authoridBozkurt, Ceyhun/0000-0001-6771-9894
dc.authorwosidKebudi, Rejin/AAD-8047-2020
dc.authorwosidBozkurt, Ceyhun/AAL-5043-2021
dc.authorwosidOztunali, Cigdem/JAX-9031-2023
dc.authorwosidErsoy, Gizem/JAX-8473-2023
dc.contributor.authorToret, Ersin
dc.contributor.authorOzdemir, Zeynep Canan
dc.contributor.authorZengin Ersoy, Gizem
dc.contributor.authorOztunali, Cigdem
dc.contributor.authorBozkurt, Ceyhun
dc.contributor.authorKebudi, Rejin
dc.date.accessioned2024-05-19T14:39:13Z
dc.date.available2024-05-19T14:39:13Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractBackgroundRetinoblastoma (RB) is the most common intraocular malignancy in childhood. Advanced RB, associated with exceedingly poor prognosis, requires more intensive multiagent chemotherapy than conventional regimens. Rescue of the bone marrow after intensive chemotherapy is achieved with stem cell transplantation. The sequential courses (tandem transplantation) of high-dose chemotherapy followed by autologous stem cell transplantation allow for even greater dose intensity in consolidation with the potential to use different active chemotherapeutics at each transplant and have proven feasible and successful in treating children with recurrent/refractory solid tumors. Case DescriptionWe report an infant with trilateral high-risk RB who received tandem high-dose chemotherapy (HDC) followed by autologous stem cell transplantation after the conventional chemotherapy. A 5-month-old female patient presented with strabismus, and the ophthalmoscopic examination showed intraocular tumoral lesions in both eyes. Magnetic resonance imaging (MRI) concluded the trilateral retinoblastoma diagnosis due to a tumoral mass in the optic chiasm. The follow-up ophthalmologic examinations and the MRI detected stable disease after six cycles of multiagent chemotherapy. ConclusionsRescue with autologous stem cell transplantation after HDC allows for an increase in chemotherapy intensity. Tandem transplantation provides the chance to perform different chemotherapeutics at each transplant and enables an increase in the chemotherapy intensity, thus providing a positive effect on disease-free survival.en_US
dc.identifier.doi10.1111/petr.14504
dc.identifier.issn1397-3142
dc.identifier.issn1399-3046
dc.identifier.issue4en_US
dc.identifier.pmid36919672en_US
dc.identifier.scopus2-s2.0-85150687399en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org10.1111/petr.14504
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4730
dc.identifier.volume27en_US
dc.identifier.wosWOS:000950364500001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofPediatric Transplantationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectAutologous Stem Cellsen_US
dc.subjectPediatricen_US
dc.subjectSolid Tumorsen_US
dc.subjectTandem Transplantationen_US
dc.subjectTrilateral Retinoblastomaen_US
dc.titleTandem high-dose chemotherapy followed by autologous stem cell transplantation: An infant with trilateral retinoblastomaen_US
dc.typeArticleen_US

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