The understanding of the immunopathology in COVID-19 infection
Yükleniyor...
Dosyalar
Tarih
2021
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Online
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Coronaviruses belonging to the Coronaviridae family are single-stranded RNA viruses. The entry of SARS-CoV-2 is accomplished via ACE-2 receptors. SARS-CoV-2 infection coactivates both innate and adaptive immune responses. Although SARS-CoV-2 stimulates antibody production with a typical pattern of IgM/IgG, cellular immunity is also impaired. In severe cases, low CD4 + and CD8 + T cell counts are associated with impaired immune functions, and high neutrophil/lymphocyte ratios accompanying low lymphocyte subsets have been demonstrated. Recently, high IFN -?/? ratios with impaired T cell responses, and increased IL-1, IL-6, TNF-?, MCP-1, IP-10, IL-4, IL-10 have been reported in COVID-19 infection. Increased proinflammatory cytokines and chemokines in patients with severe COVID-19 may cause the suppression of CD4 + and CD8 + T cells and regulatory T cells, causing excessive inflammatory responses and fatal cytokine storm with tissue and organ damage. Consequently, novel therapeutics to be developed against host immune system, including blockade of cytokines (IL-6, IL-1, IFN) themselves, their receptors or signaling pathways- JAK inhibitors- could be effective as potential therapeutics.
Açıklama
Anahtar Kelimeler
COVID-19, Chemokines, Cytokines, Immunotherapy, Pandemics
Kaynak
Scandinavian Journal of Clinical and Laboratory Investigation
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
Sayı
Künye
Tascioglu, D., Akkaya, E., & Genc, S. (2021). The understanding of the immunopathology in COVID-19 infection. Scandinavian journal of clinical and laboratory investigation, 1–9. Advance online publication. https://doi.org/10.1080/00365513.2021.1892817
