Enhancing the adhesiveness capacity of tissue adhesives: exploring the impact of silk fibroin concentration and curing time on the efficacy of corneal adhesives

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dc.authorscopusidAyça Bal Öztürk / 57062000100
dc.authorwosidAyça Bal Öztürk / KRG-6786-2024
dc.contributor.authorTanrıverdi, Ayşegül
dc.contributor.authorİzbudak, Burçin
dc.contributor.authorDastjerd, Samin
dc.contributor.authorZamani, Elaleh
dc.contributor.authorBal-Öztürk, Ayça
dc.date.accessioned2025-04-17T11:03:01Z
dc.date.available2025-04-17T11:03:01Z
dc.date.issued2025
dc.departmentİstinye Üniversitesi, Eczacılık Fakültesi, Eczacılık Temel Bilimleri Bölümü
dc.description.abstractThe current study delved into developing biocompatible silk fibroin (SF) hydrogel-based adhesives and assessed the effect of various concentrations of SF and the visible light exposure duration during the riboflavin-mediated photo-crosslinking process to promote the in vitro/ex vivo performance of them as an ocular tissue adhesive. To accomplish this purpose, the SF solution with high adhesion features that was extracted from silk cocoons underwent exposure for durations of 1, 2, and 4 min, with varying SF concentrations (7.5 %, 15 %, and 22.5 % w/ v). The physicochemical properties of the SF adhesives, such as mechanical strength and biological adhesion behaviors, were enhanced by the increase in SF contents and irradiation time that were investigated by the characterizations of the adhesives using various techniques, which was attributed to the high density of dityrosine and beta-sheet crosslinking agents in the adhesive network. Furthermore, the interaction between tyrosine residues in SF and ocular aqueous humor led to the formation of covalent di-tyrosine crosslinking, which improved the performance of the developed corneal adhesives. SF adhesives exhibited nontoxicity behaviors towards human corneal fibroblast cell lines (HCFs), and findings of DAPI/Actin and PrestoBlue assays revealed the readily adhesion and proliferation of HCFs over SF adhesives, which confirmed their biocompatibility and potential for use in corneal tissue engineering applications.
dc.identifier.citationTanrıverdi, A., İzbudak, B., Dastjerd, S., Zamani, E., & Bal-Öztürk, A. (2025). Enhancing the adhesiveness capacity of tissue adhesives: Exploring the impact of silk fibroin concentration and curing time on the efficacy of corneal adhesives. International Journal of Adhesion and Adhesives, 138, 103948.
dc.identifier.doi10.1016/j.ijadhadh.2025.103948
dc.identifier.endpage10
dc.identifier.issn0143-7496
dc.identifier.issn1879-0127
dc.identifier.scopus2-s2.0-85215761846
dc.identifier.scopusqualityQ1
dc.identifier.startpage1
dc.identifier.urihttp://dx.doi.org/10.1016/j.ijadhadh.2025.103948
dc.identifier.urihttps://hdl.handle.net/20.500.12713/6210
dc.identifier.volume138
dc.identifier.wosWOS:001411993000001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorBal-Öztürk, Ayça
dc.institutionauthoridAyça Bal Öztürk / 0000-0002-6502-528X
dc.language.isoen
dc.publisherElsevier ltd
dc.relation.ispartofInternational ojurnal of adhesion and adhesives
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectHydrogel
dc.subjectOcular Adhesives
dc.subjectPhoto-Crosslinking
dc.subjectRiboflavin
dc.subjectSilk Fibroin
dc.subjectTyrosine
dc.titleEnhancing the adhesiveness capacity of tissue adhesives: exploring the impact of silk fibroin concentration and curing time on the efficacy of corneal adhesives
dc.typeArticle

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