The Use of Pre-Chemoradiotherapy Total Masseter Muscle Volume as a Novel Predictor of Radiation-Induced Trismus in Locally Advanced Nasopharyngeal Carcinoma Patients

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dc.authoridselek, ugur/0000-0001-8087-3140
dc.authoridMertsoylu, Hüseyin/0000-0002-1932-9784
dc.authoridTopkan, Erkan/0000-0001-8120-7123
dc.authoridPehlivan, Umur Anil/0000-0001-5871-0695
dc.authoridYilmaz, Busra/0000-0003-0633-5648
dc.authoridSomay, efsun/0000-0001-8251-6913
dc.authorwosidselek, ugur/O-5474-2014
dc.authorwosidMertsoylu, Hüseyin/M-9530-2014
dc.authorwosidTopkan, Erkan/AAG-2213-2021
dc.contributor.authorSomay, Efsun
dc.contributor.authorTopkan, Erkan
dc.contributor.authorPehlivan, Umur Anil
dc.contributor.authorYilmaz, Busra
dc.contributor.authorBesen, Ali Ayberk
dc.contributor.authorMertsoylu, Huseyin
dc.contributor.authorPehlivan, Berrin
dc.date.accessioned2024-05-19T14:45:45Z
dc.date.available2024-05-19T14:45:45Z
dc.date.issued2024
dc.departmentİstinye Üniversitesien_US
dc.description.abstractBackground: We sought to determine whether pretreatment total masseter muscle volume (TMMV) measures can predict radiation-induced trismus (RIT) in patients with locally advanced nasopharyngeal carcinoma (LA-NPC) receiving concurrent chemoradiotherapy (C-CRT). Methods: We retrospectively reviewed the medical records of LA-NPC patients who received C-CRT and had pretreatment maximum mouth openings (MMO) greater than 35 mm. MMO of 35 mm or less after C-CRT were considered RIT. We employed receiver operating characteristic (ROC) curve analysis to explore the correlation between pre-treatment TMMV readings and RIT status. Results: Out of the 112 eligible patients, 22.0% of them received a diagnosis of RIT after C-CRT. The optimal TMMV cutoff that was significantly linked to post-C-CRT RIT rates was determined to be 35.0 cc [area under the curve: 79.5%; sensitivity: 75.0%; and specificity: 78.6%; Youden index: 0.536] in the ROC curve analysis. The incidence of RIT was significantly higher in patients with TMMV <= 5.0 cc than in those with TMMV > 35.0 cc [51.2% vs. 8.7%; Odds ratio: 6.79; p < 0.001]. A multivariate logistic regression analysis revealed that pre-C-CRT MMO <= 41.6 mm (p = 0.001), mean masticatory apparatus dose V56.5 >= 34% group (p = 0.002), and TMMV <= 35 cc were the independent predictors of significantly elevated rates of RIT. Conclusion: The presence of a smaller pretreatment TMMV is a reliable and independent novel biological marker that can confidently predict higher RIT rates in LA-NPC patients who receive C-CRT.en_US
dc.identifier.doi10.3390/tomography10010007
dc.identifier.endpage89en_US
dc.identifier.issn2379-1381
dc.identifier.issn2379-139X
dc.identifier.issue1en_US
dc.identifier.pmid38250953en_US
dc.identifier.scopus2-s2.0-85183083423en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage79en_US
dc.identifier.urihttps://doi.org10.3390/tomography10010007
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5334
dc.identifier.volume10en_US
dc.identifier.wosWOS:001152831300001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofTomographyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectMasseter Muscle Volumeen_US
dc.subjectConcurrent Chemoradiotherapyen_US
dc.subjectNasopharyngeal Canceren_US
dc.subjectRadiation-Induced Trismusen_US
dc.titleThe Use of Pre-Chemoradiotherapy Total Masseter Muscle Volume as a Novel Predictor of Radiation-Induced Trismus in Locally Advanced Nasopharyngeal Carcinoma Patientsen_US
dc.typeArticleen_US

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