Biosensor integrated brain-on-a-chip platforms: Progress and prospects in clinical translation

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dc.authoridTOPKAYA, SEDA NUR/0000-0002-7816-3155
dc.authoridZarepour, Atefeh/0000-0002-0347-5840
dc.authoridCecen, Berivan/0000-0002-0081-2004
dc.authoridsaygili, ecem/0000-0002-8389-9079
dc.authoridMostafavi, Ebrahim/0000-0003-3958-5002
dc.authorwosidTOPKAYA, SEDA NUR/GLT-5663-2022
dc.authorwosidZarepour, Atefeh/AAH-9225-2020
dc.authorwosidYesil-Celiktas, Ozlem/JCE-6028-2023
dc.authorwosidYesil-Celiktas, Ozlem/AAI-5713-2020
dc.authorwosidCecen, Berivan/Q-4203-2019
dc.authorwosidsaygili, ecem/GRF-3601-2022
dc.authorwosidMostafavi, Ebrahim/X-3674-2019
dc.contributor.authorCecen, Berivan
dc.contributor.authorSaygili, Ecem
dc.contributor.authorZare, Iman
dc.contributor.authorNejati, Omid
dc.contributor.authorKhorsandi, Danial
dc.contributor.authorZarepour, Atefeh
dc.contributor.authorAlarcin, Emine
dc.date.accessioned2024-05-19T14:39:34Z
dc.date.available2024-05-19T14:39:34Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractBecause of the brain's complexity, developing effective treatments for neurological disorders is a formidable challenge. Research efforts to this end are advancing as in vitro systems have reached the point that they can imitate critical components of the brain's structure and function. Brain-on-a-chip (BoC) was first used for microfluidics-based systems with small synthetic tissues but has expanded recently to include in vitro simulation of the central nervous system (CNS). Defining the system's qualifying parameters may improve the BoC for the next generation of in vitro platforms. These parameters show how well a given platform solves the problems unique to in vitro CNS modeling (like recreating the brain's microenvironment and including essential parts like the blood-brain barrier (BBB)) and how much more value it offers than traditional cell culture systems. This review provides an overview of the practical concerns of creating and deploying BoC systems and elaborates on how these technologies might be used. Not only how advanced biosensing technologies could be integrated with BoC system but also how novel approaches will automate assays and improve point-of-care (PoC) diagnostics and accurate quantitative analyses are discussed. Key challenges providing opportunities for clinical translation of BoC in neurodegenerative disorders are also addressed.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [221M724]; National Institute of Biomedical Imaging and Bioengineering [5T32EB009035]; Research Fund of Ege University, International Research Cooperation Project [FUA- 2020-22187]en_US
dc.description.sponsorshipA.B.O acknowledges the support from the Scientific and Techno- logical Research Council of Turkey (TUBITAK) (221M724) . E.M. would like to acknowledge the support from the National Institute of Biomedical Imaging and Bioengineering (5T32EB009035) . O.Y.C. ac- knowledges the support from the Research Fund of Ege University, In- ternational Research Cooperation Project under grant number FUA- 2020-22187.en_US
dc.identifier.doi10.1016/j.bios.2023.115100
dc.identifier.issn0956-5663
dc.identifier.issn1873-4235
dc.identifier.pmid36709589en_US
dc.identifier.scopus2-s2.0-85147253880en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org10.1016/j.bios.2023.115100
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4806
dc.identifier.volume225en_US
dc.identifier.wosWOS:000926741900001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Advanced Technologyen_US
dc.relation.ispartofBiosensors & Bioelectronicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectBrain-On-A-Chipen_US
dc.subjectBiosensoren_US
dc.subjectIntegrated Biosensorsen_US
dc.subjectMicrophysiological Systemsen_US
dc.subjectMicrofluidicsen_US
dc.subjectOrgan-On-Chipen_US
dc.subjectMicrofabricationen_US
dc.titleBiosensor integrated brain-on-a-chip platforms: Progress and prospects in clinical translationen_US
dc.typeArticleen_US

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