Pre-clinical and clinical importance of mir-21 in human cancers: tumorigenesis, therapy response, delivery approaches and targeting agents

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dc.authoridAli Zarrabi / 0000-0003-0391-1769en_US
dc.authorscopusidAli Zarrabi / 23483174100en_US
dc.authorwosidAli Zarrabi / U-2602-2019en_US
dc.contributor.authorHashemi, Mehrdad
dc.contributor.authorMirdamadi, Motahare Sadat Ayat
dc.contributor.authorTalebi, Yasmin
dc.contributor.authorKhaniabad, Nasrin
dc.contributor.authorBanaei, Gooya
dc.contributor.authorDaneii, Pouria
dc.contributor.authorGholami, Sadaf
dc.contributor.authorGhorbani, Amin
dc.contributor.authorZarrabi, Ali
dc.date.accessioned2022-12-30T14:21:23Z
dc.date.available2022-12-30T14:21:23Z
dc.date.issued2023en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.description.abstractThe field of non-coding RNA (ncRNA) has made significant progress in understanding the pathogenesis of diseases and has broadened our knowledge towards their targeting, especially in cancer therapy. ncRNAs are a large family of RNAs with microRNAs (miRNAs) being one kind of endogenous RNA which lack encoded proteins. By now, miRNAs have been well-coined in pathogenesis and development of cancer. The current review focuses on the role of miR-21 in cancers and its association with tumor progression. miR-21 has both oncogenic and onco-suppressor functions and most of the experiments are in agreement with the tumor-promoting function of this miRNA. miR-21 primarily decreases PTEN expression to induce PI3K/Akt signaling in cancer progression. Overexpression of miR-21 inhibits apoptosis and is vital for inducing pro-survival autophagy. miR-21 is vital for metabolic reprogramming and can induce glycolysis to enhance tumor progression. miR-21 stimulates EMT mechanisms and increases expression of MMP-2 and MMP-9 thereby elevating tumor metastasis. miR-21 is a target of anti-cancer agents such as curcumin and curcumol and its down-regulation impairs tumor progression. Upregulation of miR-21 results in cancer resistance to chemotherapy and radiotherapy. Increasing evidence has revealed the role of miR-21 as a biomarker as it is present in both the serum and exosomes making them beneficial biomarkers for non-invasive diagnosis of cancer.en_US
dc.identifier.citationHashemi, M., Mirdamadi, M. S. A., Talebi, Y., Khaniabad, N., Banaei, G., Daneii, P., ... & Khan, H. (2022). Pre-clinical and clinical importance of miR-21 in human cancers: Tumorigenesis, therapy response, delivery approaches and targeting agents. Pharmacological Research, 106568.en_US
dc.identifier.doi10.1016/j.phrs.2022.106568en_US
dc.identifier.issn1043-6618en_US
dc.identifier.issn1096-1186en_US
dc.identifier.scopus2-s2.0-85145675967en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.phrs.2022.106568
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3806
dc.identifier.volume187en_US
dc.identifier.wosWOS:000896027300002en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZarrabi, Ali
dc.language.isoenen_US
dc.publisherACADEMIC PRESS LTD- ELSEVIER SCIENCE LTDen_US
dc.relation.ispartofPHARMACOLOGICAL RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMicroRNAen_US
dc.subjectNon-Coding RNAen_US
dc.subjectLncRNAen_US
dc.subjectCircRNAen_US
dc.subjectDrug Resistanceen_US
dc.subjectImmune Evasionen_US
dc.titlePre-clinical and clinical importance of mir-21 in human cancers: tumorigenesis, therapy response, delivery approaches and targeting agentsen_US
dc.typeArticleen_US

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