Gene regulation by antisense transcription: a focus on neurological and cancer diseases

Basit Öğe Kaydı
dc.authoridAli Zarrabi / 0000-0003-0391-1769en_US
dc.authorscopusidAli Zarrabi / 23483174100
dc.authorwosidAli Zarrabi / U-2602-2019
dc.contributor.authorNajaf, Sajad
dc.contributor.authorTan, Shing Cheng
dc.contributor.authorRaee, Pourya
dc.contributor.authorRahmati, Yazdan
dc.contributor.authorAsemani, Yahya
dc.contributor.authorLee, E. Hui Clarissa
dc.contributor.authorHushmandi, Kiavash
dc.contributor.authorAref, Amir Reza
dc.date.accessioned2021-11-11T11:54:35Z
dc.date.available2021-11-11T11:54:35Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.description.abstractAdvances in high-throughput sequencing over the past decades have led to the identification of thousands of non-coding RNAs (ncRNAs), which play a major role in regulating gene expression. One emerging class of ncRNAs is the natural antisense transcripts (NATs), the RNA molecules transcribed from the opposite strand of a protein-coding gene locus. NATs are known to concordantly and discordantly regulate gene expression in both cis and trans manners at the transcriptional, post-transcriptional, translational, and epigenetic levels. Aberrant expression of NATs can therefore cause dysregulation in many biological pathways and has been observed in many genetic diseases. This review outlines the involvements and mechanisms of NATs in the pathogenesis of various diseases, with a special emphasis on neurodegenerative diseases and cancer. We also summarize recent findings on NAT knockdown and/or overexpression experiments and discuss the potential of NATs as promising targets for future gene therapies.en_US
dc.identifier.citationSajad Najafi, Shing Cheng Tan, Pourya Raee, Yazdan Rahmati, Yahya Asemani, E. Hui Clarissa Lee, Kiavash Hushmandi, Ali Zarrabi, Amir Reza Aref, Milad Ashrafizadeh, Alan Prem Kumar, Yavuz Nuri Ertas, Sepideh Ghani & Shahin Aghamiri (2022). Gene regulation by antisense transcription: A focus on neurological and cancer diseases. Biomedicine & Pharmacotherapy 145.en_US
dc.identifier.doi10.1016/j.biopha.2021.112265en_US
dc.identifier.pmid34749054en_US
dc.identifier.scopus2-s2.0-85118583573en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1016/j.biopha.2021.112265
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2225
dc.identifier.volume145en_US
dc.identifier.wosWOS:000724985500004en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZarrabi, Ali
dc.language.isoenen_US
dc.publisherScience Directen_US
dc.relation.ispartofBiomedicine & Pharmacotherapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntisense RNAen_US
dc.subjectCanceren_US
dc.subjectLong Non-Coding RNAen_US
dc.subjectNeurodegenerative Diseasesen_US
dc.subjectTherapeutic Targetsen_US
dc.titleGene regulation by antisense transcription: a focus on neurological and cancer diseasesen_US
dc.typeReview Articleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
205.pdf
Boyut:
4.31 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Biyomedikal Mühendisliği Bölümü Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu