Can Amphotericin B-mediated effects be limited using intranasal versus intravenous route?

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dc.authoridSiddiqui, Ruqaiyyah/0000-0001-9646-6208
dc.authoridKhan, Naveed/0000-0001-7667-8553
dc.authorwosidSiddiqui, Ruqaiyyah/AIF-2100-2022
dc.authorwosidKhan, Naveed/KCK-0156-2024
dc.authorwosidKhan, Naveed/AAM-2892-2021
dc.contributor.authorSiddiqui, Ruqaiyyah
dc.contributor.authorOng, Timothy Yu Yee
dc.contributor.authorMaciver, Sutherland
dc.contributor.authorKhan, Naveed Ahmed
dc.date.accessioned2024-05-19T14:38:54Z
dc.date.available2024-05-19T14:38:54Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractAim: CNS infections due to parasites often prove fatal. In part, this is due to inefficacy of drugs to cross the blood-brain barrier. Methods: Here, we tested intranasal and intravenous route and compared adverse effects of Amphotericin B administration, through blood biochemistry, liver, kidney and brain histopathological evidence of toxicities in vivo post-administration. Results: It was observed that intranasal route limits the adverse side effects of Amphotericin B, in contrast to intravenous route. Conclusion: As parasites such as Naegleria fowleri exhibit unequivocal affinity toward the olfactory bulb and frontal lobe in the central nervous system, intranasal administration would directly reach amoebae bypassing the blood-brain barrier selectivity and achieve the minimum inhibitory concentration at the target site. Plain language summary: Brain infections due to parasites are often fatal. One of the reasons is the inability of drugs to get to the brain. When given in large dose to reach the brain, the drug can cause serious side effects. Here, we tested the side effects of Amphotericin B (drug of choice against brain-eating amoebae), when given intranasally versus intravenous. Our findings clearly show that intranasal route limits the side effects of Amphotericin B. These are important findings and should serve as an important step in the development of effective therapy against parasitic infections affecting the brain. Tweetable abstract: Targeting brain-eating amoebae: Amphotericin B-mediated host tissue toxicity can be limited when given intranasally. [GRAPHICS.]en_US
dc.description.sponsorshipSunway University [2017-04]en_US
dc.description.sponsorshipThis work was supported by Sunway University internal grant (2017-04). This work was supported by Sunway University internal grant (2017-04). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.en_US
dc.identifier.doi10.4155/tde-2023-0032
dc.identifier.issn2041-5990
dc.identifier.issn2041-6008
dc.identifier.pmid37691579en_US
dc.identifier.scopus2-s2.0-85171309212en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org10.4155/tde-2023-0032
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4643
dc.identifier.wosWOS:001065270700001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherNewlands Press Ltden_US
dc.relation.ispartofTherapeutic Deliveryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectAdverse Effectsen_US
dc.subjectAmphotericin Ben_US
dc.subjectBlood-Brain Barrieren_US
dc.subjectBrain-Eating Amoebaeen_US
dc.subjectCns Infectionen_US
dc.subjectFree-Living Amoebaeen_US
dc.subjectIntranasal Routeen_US
dc.subjectNaegleria Fowlerien_US
dc.subjectNovel Therapeutic Deliveryen_US
dc.subjectPrimary Amoebic Meningoencephalitisen_US
dc.titleCan Amphotericin B-mediated effects be limited using intranasal versus intravenous route?en_US
dc.typeArticleen_US

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