Long-term mortality risk in obstructive sleep apnea: the critical role of oxygen desaturation index
Yükleniyor...
Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer Science and Business Media Deutschland GmbH
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: Mortality predictors in obstructive sleep apnea (OSA) patients yet to be comprehensively understood, especially within large cohorts undergoing long-term follow-up. We aimed to determine the independent predictors of mortality in OSA patients. Methods: In our retrospective cohort study, 3,541 patients were included and survival data was obtained from electronic medical records. Demographic characteristics, anthropometric measurements, comorbidities, laboratory tests, and polysomnography parameters were analyzed for the survived and deceased patient groups. Univariate and multivariate Cox regression analyses were performed to determine independent predictors of all-cause mortality in patients followed for at least 5 years. Results: Among all patients, 2,551 (72%) patients were male, with a mean age of 49.7 years. 231 (6.5%) patients had died. Deceased patients were significantly older and had higher waist-to-hip ratio and Epworth Sleepiness Scale (p < 0.001, p < 0.001, p = 0.003). OSA (nonpositional and not-rapid eye movement-related), periodic limb movements in sleep and Comorbidities of Sleep Apnea Score ≥ 1 were found to be associated with increased mortality (p < 0.001). Systemic immune-inflammation index was also significantly higher in the deceased group (p < 0.001). Higher oxygen desaturation index (ODI) and apnea-hypopnea index (AHI) were associated with increased mortality (p < 0.001). Due to the high correlation between ODI and AHI, two separate multivariate Cox regression models were created. While AHI lost its significance in the multivariate analysis, ODI remained significantly higher in the deceased patient group (HR = 1.007, 1.001–1.013, p = 0.01). Conclusion: ODI, as the only polysomnography parameter, emerged as an independent predictor of mortality in OSA patients. © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2024.
Açıklama
Anahtar Kelimeler
AHI, Mortality Predictors, Obstructive Sleep Apnea, ODI
Kaynak
Sleep and Breathing
WoS Q Değeri
Q3
Scopus Q Değeri
Q1
Cilt
28
Sayı
6
Künye
Azakli, D., Satici, C., Sokucu, S. N., Aydin, S., Atasever, F., & Ozdemir, C. (2024). Long-term mortality risk in obstructive sleep apnea: the critical role of oxygen desaturation index. Sleep and Breathing, 1-12.
