Long-term mortality risk in obstructive sleep apnea: the critical role of oxygen desaturation index

Basit Öğe Kaydı
dc.authorscopusidCengiz Özdemir / 56343360100
dc.authorwosidCengiz Özdemir / H-2105-2018
dc.contributor.authorAzaklı, Damla
dc.contributor.authorSatıcı, Celal
dc.contributor.authorSokucu, Sinem Nedime
dc.contributor.authorAydın, Şenay
dc.contributor.authorAtasever, Furkan
dc.contributor.authorÖzdemir, Cengiz
dc.date.accessioned2025-04-18T10:49:54Z
dc.date.available2025-04-18T10:49:54Z
dc.date.issued2024
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractBackground: Mortality predictors in obstructive sleep apnea (OSA) patients yet to be comprehensively understood, especially within large cohorts undergoing long-term follow-up. We aimed to determine the independent predictors of mortality in OSA patients. Methods: In our retrospective cohort study, 3,541 patients were included and survival data was obtained from electronic medical records. Demographic characteristics, anthropometric measurements, comorbidities, laboratory tests, and polysomnography parameters were analyzed for the survived and deceased patient groups. Univariate and multivariate Cox regression analyses were performed to determine independent predictors of all-cause mortality in patients followed for at least 5 years. Results: Among all patients, 2,551 (72%) patients were male, with a mean age of 49.7 years. 231 (6.5%) patients had died. Deceased patients were significantly older and had higher waist-to-hip ratio and Epworth Sleepiness Scale (p < 0.001, p < 0.001, p = 0.003). OSA (nonpositional and not-rapid eye movement-related), periodic limb movements in sleep and Comorbidities of Sleep Apnea Score ≥ 1 were found to be associated with increased mortality (p < 0.001). Systemic immune-inflammation index was also significantly higher in the deceased group (p < 0.001). Higher oxygen desaturation index (ODI) and apnea-hypopnea index (AHI) were associated with increased mortality (p < 0.001). Due to the high correlation between ODI and AHI, two separate multivariate Cox regression models were created. While AHI lost its significance in the multivariate analysis, ODI remained significantly higher in the deceased patient group (HR = 1.007, 1.001–1.013, p = 0.01). Conclusion: ODI, as the only polysomnography parameter, emerged as an independent predictor of mortality in OSA patients. © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2024.
dc.identifier.citationAzakli, D., Satici, C., Sokucu, S. N., Aydin, S., Atasever, F., & Ozdemir, C. (2024). Long-term mortality risk in obstructive sleep apnea: the critical role of oxygen desaturation index. Sleep and Breathing, 1-12.
dc.identifier.doi10.1007/s11325-024-03137-7
dc.identifier.endpage2378
dc.identifier.issn15209512
dc.identifier.issue6
dc.identifier.pmid39120771
dc.identifier.scopus2-s2.0-85200991516
dc.identifier.scopusqualityQ1
dc.identifier.startpage2367
dc.identifier.urihttp://dx.doi.org/10.1007/s11325-024-03137-7
dc.identifier.urihttps://hdl.handle.net/20.500.12713/7206
dc.identifier.volume28
dc.identifier.wosWOS:001288049900001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakWeb of Science
dc.institutionauthorÖzdemir, Cengiz
dc.institutionauthoridCengiz Özdemir / 0000-0002-9816-8885
dc.language.isoen
dc.publisherSpringer Science and Business Media Deutschland GmbH
dc.relation.ispartofSleep and Breathing
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAHI
dc.subjectMortality Predictors
dc.subjectObstructive Sleep Apnea
dc.subjectODI
dc.titleLong-term mortality risk in obstructive sleep apnea: the critical role of oxygen desaturation index
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
Longterm-mortality-risk-in-obstructive-sleep-apnea-the-critical-role-of-oxygen-desaturation-indexSleep-and-Breathing.pdf
Boyut:
1.24 MB
Biçim:
Adobe Portable Document Format
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.17 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Dahili Tıp Bilimleri Bölümü Makale Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu