Comparison of the efficacy of 5% versus 8% acetic acid concentrations for detecting premalignant and malignant lesions in colposcopy

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dc.authoridGülbahar, Ayşegül/0000-0001-6533-6195
dc.authorwosidGülbahar, Ayşegül/JCD-5404-2023
dc.contributor.authorYilmaz, Alpay
dc.contributor.authorGulbahar, Aysegul
dc.contributor.authorSen, Serhat
dc.date.accessioned2024-05-19T14:38:48Z
dc.date.available2024-05-19T14:38:48Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractAlthough preventable; cervical cancer remains a significant cause of morbidity and mortality worldwide, especially in developing countries; thus, early diagnosis and treatment are essential to prevent its development into invasive cancer. Based on the screening results, diagnostic colposcopy was performed to evaluate women with abnormal Papinocalaou test results, high-risk human papillomavirus DNA positivity, or suspected cervical cancer. Therefore, this study aimed to determine the optimal acetic acid concentration (5% or 8%) for detecting cervical precancerous/cancerous lesions during colposcopy evaluation. This study included 607 patients admitted to our obstetrics and gynecology clinic. The medical records of the patients were obtained from the colposcopy registry in the hospital information system and retrospectively analyzed. The cases were divided into 2 groups according to the acetic acid concentrations (5% and 8%) used during colposcopy and examined. The duration of acetic acid application was 2 to 4 minutes. The probability of developing >= CIN2 was low in patients with negative for intraepithelial lesion or malignancy smear results in both groups, but increased in the high-grade squamous intraepithelial lesions/atypical squamous cells group with the 8% acetic acid concentration (P < .0001; P = .012). The probabilities of pathological detection of >= CIN2 in the 5% and 8% acetic acid groups were 17.3% and 46.6%, respectively (P < .0001). The enhancement of the efficiency of colposcopy should focus on improving the detectability of precancerous lesions. Given that this study compared the effectiveness of acetic acid concentration in colposcopy diagnostics, it can be considered a leading study in this field.en_US
dc.identifier.doi10.1097/MD.0000000000036341
dc.identifier.issn0025-7974
dc.identifier.issn1536-5964
dc.identifier.issue50en_US
dc.identifier.pmid38115367en_US
dc.identifier.scopus2-s2.0-85180082179en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org10.1097/MD.0000000000036341
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4609
dc.identifier.volume102en_US
dc.identifier.wosWOS:001127027700040en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofMedicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectAcetic Aciden_US
dc.subjectCervical Canceren_US
dc.subjectColposcopic Surgeryen_US
dc.subjectHuman Papilloma Virusen_US
dc.titleComparison of the efficacy of 5% versus 8% acetic acid concentrations for detecting premalignant and malignant lesions in colposcopyen_US
dc.typeArticleen_US

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