Prognostic significance of carbonic anhydrase IX overexpression in stage III non-small cell lung cancer patients after neoadjuvant treatment

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dc.authoridVeysel Sabri Hançer / 0000-0003-2994-1077en_US
dc.authorscopusidVeysel Sabri Hançer / 6506533543
dc.authorwosidVeysel Sabri Hançer / X-8971-2018
dc.contributor.authorİbiş, Kamuran
dc.contributor.authorSağlam, Sezer
dc.contributor.authorSağlam, Esra Kaytan
dc.contributor.authorFırat, Pınar
dc.contributor.authorYılmazbayhan, Dilek
dc.contributor.authorToker, Alper
dc.contributor.authorÖzkan, Berker
dc.contributor.authorHançer, Veysel Sabri
dc.contributor.authorBüyükdoğan, Murat
dc.contributor.authorDisci, Rian
dc.contributor.authorPilancı, Kezban Nur
dc.date.accessioned2020-08-30T20:07:22Z
dc.date.available2020-08-30T20:07:22Z
dc.date.issued2018
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: To assess the prognostic importance of carbonic anhydrase IX (CA IX), a hypoxic biomarker, after neoadjuvant treatment in Stage III non-small cell lung cancer (NSCLC) patients. Methods: Tissue CA IX expression was examined after surgical resection in 77 patients who had undergone neoadjuvant treatment. The effects of CA IX overexpression and other clinical factors on disease-free survival and overall survival were investigated. Results: In multivariate analysis, number of neoadjuvant chemotherapy (CT) courses and gender emerged as significant independent predictors for disease-free survival, where administration of 2-3 courses of neoadjuvant chemotherapy (CT) (HR, 3.2 [95% CI 1.3-7.6], p = 0.009) and female gender were associated with poor survival (HR, 3.2 [95% CI 1.3-7.7], p = 0.009). The only significant independent predictor for overall survival was recurrence (HR, 5.6 [95% CI 2.4-12.8], p < 0.001). On the other hand, CA IX overexpression was not associated with disease free survival (p = 0.560) or overall survival (p = 0.799). Discussion: Our results do not suggest a prognostic role for CA IX overexpression in stage III NSCLC patients who received neoadjuvant treatment.en_US
dc.description.sponsorshipTurkish Medical Oncology Society [P-TFOD-2015-17]en_US
dc.description.sponsorshipThis study was funded by Turkish Medical Oncology Society(P-TFOD-2015-17)en_US
dc.identifier.citationIbis, K., Saglam, S., Saglam, E. K., Firat, P., Yilmazbayhan, D., Toker, A., … Pilanci, K. N. (2018). Prognostic significance of carbonic anhydrase IX overexpression in stage III non-small cell lung cancer patients after neoadjuvant treatment. Pathology Research and Practice, 214(9), 1291–1296. https://doi.org/10.1016/j.prp.2018.07.010en_US
dc.identifier.doi10.1016/j.prp.2018.07.010en_US
dc.identifier.endpage1296en_US
dc.identifier.issn0344-0338en_US
dc.identifier.issue9en_US
dc.identifier.pmid30029935en_US
dc.identifier.scopus2-s2.0-85049898019en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1291en_US
dc.identifier.urihttps://doi.org/10.1016/j.prp.2018.07.010
dc.identifier.urihttps://hdl.handle.net/20.500.12713/749
dc.identifier.volume214en_US
dc.identifier.wosWOS:000445973500008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorHançer, Veysel Sabrien_US
dc.language.isoenen_US
dc.publisherElsevier Gmbh, Urban & Fischer Verlagen_US
dc.relation.ispartofPathology Research and Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNon-Small Cell Lung Cancer (Nsclc)en_US
dc.subjectCarbonic Anhydrase Ix (Ca Dc)en_US
dc.subjectNeoadjuvant Treatmenten_US
dc.subjectPrognosisen_US
dc.subjectOverall Survivalen_US
dc.subjectDisease Free Survivalen_US
dc.titlePrognostic significance of carbonic anhydrase IX overexpression in stage III non-small cell lung cancer patients after neoadjuvant treatmenten_US
dc.typeArticleen_US

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