Serum asprosin levels in patients with retinopathy of prematurity

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dc.authoridDidem Cemile Yeşilırmak / 0000-0002-2766-2835
dc.authorscopusidDidem Cemile Yeşilırmak / 6508165699
dc.authorwosidDidem Cemile Yeşilırmak / GKP-8125-2022en_US
dc.contributor.authorYardım, Meltem
dc.contributor.authorÇelik, Fatih
dc.contributor.authorOruç, Yavuz
dc.contributor.authorKayalp, Damla
dc.contributor.authorBeyazyıldız, Özlem
dc.contributor.authorYeşilırmak, Didem Cemile
dc.contributor.authorUlaş, Mustafa
dc.contributor.authorAydın, Süleyman
dc.date.accessioned2022-09-16T12:38:35Z
dc.date.available2022-09-16T12:38:35Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Hastaneen_US
dc.description.abstractObjectives This study was aimed to investigate the diagnostic values of serum levels of asprosin and neutrophil gelatinase-associated lipocalin (NGAL) in Retinopathy of prematurity (ROP) and to assess the role of these biomarkers on the development and progression of the condition. Methods This study was carried out from April 2020 to February 2021 in the department of ophthalmology of a tertiary hospital in Turkey. Thirty patients diagnosed with ROP and 30 healthy newborns were included the study. Serum NGAL and asprosin levels were determined via ELISA. Results The median serum NGAL levels were found to be similar between the ROP group and the control group (p=0.595). Median asprosin levels were significantly higher in patients diagnosed with ROP [46.58 (12.70-142.28) ng/mL] compared to healthy subjects [13.05 (10.92-17.73) ng/mL] (p=0.001). The optimal cut-off value of asprosin by ROC analysis was 30 ng/mL (AUC: 0.754, p=0.001) for diagnosing ROP. Serum asprosin levels were positively correlated with serum ALP levels and inversely correlated with gestational week, uric acid and AST values (all, p<0.005). Conclusions Our results demonstrated that asprosin, but not NGAL, could be a biomarker for the diagnosis of ROP.en_US
dc.identifier.citationYardim, M., Celik, F., Oruc, Y., Kayalp, D., Beyazyildiz, O., Yesilirmak, D. C., Ulas, M., Aydin, S. (2022). Serum asprosin levels in patients with retinopathy of prematurity. Turkish Journal of Biochemistry.en_US
dc.identifier.doi10.1515/tjb-2022-0019en_US
dc.identifier.issn0250-4685en_US
dc.identifier.scopus2-s2.0-85137663063en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.trdizinid1173735en_US
dc.identifier.urihttps://doi.org/10.1515/tjb-2022-0019
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3150
dc.identifier.wosWOS:000850297000001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorYeşilırmak, Didem Cemile
dc.language.isoenen_US
dc.publisherWALTER DE GRUYTERen_US
dc.relation.ispartofTURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISIen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAsprosinen_US
dc.subjectDiagnosticen_US
dc.subjectNeutrophil Gelatinase-Associated Lipocalinen_US
dc.subjectPrematurityen_US
dc.subjectRetinaen_US
dc.subjectRetinopathy of Prematurityen_US
dc.titleSerum asprosin levels in patients with retinopathy of prematurityen_US
dc.typeArticleen_US

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