Pd(II) and Pt(II) saccharinate complexes of bis(diphenylphosphino) propane/butane: synthesis, structure, antiproliferative activity and mechanism of action

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dc.authoridEngin Ulukaya / 0000-0003-4875-5472
dc.authoridMerve Erkısa Genel / 0000-0002-3127-742X
dc.authorscopusidEngin Ulukaya / 6602927353
dc.authorscopusidMerve Erkısa Genel / 57126208900
dc.authorwosidEngin Ulukaya / K-5792-2018
dc.authorwosidMerve Erkısa Genel / AAM-1001-2020
dc.contributor.authorYılmaz, Veysel T.
dc.contributor.authorİçsel, Ceyda
dc.contributor.authorAygün, Muhittin
dc.contributor.authorErkısa Genel, Merve
dc.contributor.authorUlukaya, Engin
dc.date.accessioned2020-08-30T20:07:17Z
dc.date.available2020-08-30T20:07:17Z
dc.date.issued2018
dc.departmentİstinye Üniversitesi, Rektörlüken_US
dc.description.abstract[M(sac)(2)(dppp)] (1 and 2), [M(dppp)(2)](sac)(2) (3 and 4) and [M(sac)(2)(dppb)] (5 and 6) complexes, where M = Pd-II (1, 3 and 5) and Pt-II (2, 4 and 6), sac = saccharinate, dppp = 1,3-bis(diphenylphosphino)propane and dppb = 1,4-bis(diphenylphosphino)butane, were synthesized and characterized by IR, NMR, ESI-MS and X-ray diffraction. The anticancer activity of the complexes against human lung (A549), breast (MCF-7), prostate (DU145) and colon (HCT116) cancer cell lines showed that the cationic complexes of dppp (3 and 4) and neutral Pt complex of dppb (6) were the most active agents of series. 3 and 4 exhibited antiproliferative activity, while 6 was highly cytotoxic compared to cisplatin. These complexes were therefore subjected to further investigations to ascertain the possible role of lipophilicity, cellular uptake and DNA/EISA binding in their biological activity. Flow cytometry analysis revealed that complex 6 induced apoptotic cell death in A549 and HCT116 cells and caused the cell cycle arrest at the S phase and overproduction of reactive oxygen species (ROS), giving rise to mitochondria) depolarization and DNA damage. (C) 2018 Elsevier Masson SAS. All rights reserved.en_US
dc.description.sponsorshipTUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [215Z230]en_US
dc.description.sponsorshipThe authors gratefully acknowledge the financial support from TUBITAK given to the research project 215Z230 and are also thankful to Dr. Buse Cevatemre for her help with the anticancer activity studies.en_US
dc.identifier.citationYilmaz, V. T., Icsel, C., Aygun, M., Erkisa, M., & Ulukaya, E. (2018). Pd(II) and Pt(II) saccharinate complexes of bis(diphenylphosphino)propane/butane: Synthesis, structure, antiproliferative activity and mechanism of action. European Journal of Medicinal Chemistry, 158, 534–547. https://doi.org/10.1016/j.ejmech.2018.09.035en_US
dc.identifier.doi10.1016/j.ejmech.2018.09.035en_US
dc.identifier.endpage547en_US
dc.identifier.issn0223-5234en_US
dc.identifier.issn1768-3254en_US
dc.identifier.pmid30243155en_US
dc.identifier.scopus2-s2.0-85053506474en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage534en_US
dc.identifier.urihttps://doi.org/10.1016/j.ejmech.2018.09.035
dc.identifier.urihttps://hdl.handle.net/20.500.12713/734
dc.identifier.volume158en_US
dc.identifier.wosWOS:000448094000039en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorErkısa Genel, Merveen_US
dc.institutionauthorUlukaya, Enginen_US
dc.language.isoenen_US
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevieren_US
dc.relation.ispartofEuropean Journal of Medicinal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPd(Ii) And Pt(Ii)en_US
dc.subjectSaccharinateen_US
dc.subjectBis(Diphenylphosphino)Propane/Butaneen_US
dc.subjectA549 Lung Cancer Cellen_US
dc.subjectHct116 Colon Cancer Cellen_US
dc.subjectAnticancer Mechanismen_US
dc.titlePd(II) and Pt(II) saccharinate complexes of bis(diphenylphosphino) propane/butane: synthesis, structure, antiproliferative activity and mechanism of actionen_US
dc.typeArticleen_US

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