Does papillary muscle free strain has predictive value in risk stratification of patients with hypertrophic cardiomyopathy?

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dc.authoridyildiz, cennet/0000-0003-2456-3206
dc.authorwosidYildiz, Cennet/HQY-3314-2023
dc.authorwosidKalkan, Sedat/GWN-0098-2022
dc.contributor.authorKoyuncu, Atilla
dc.contributor.authorYildiz, Cennet
dc.contributor.authorOcal, Lutfu
dc.contributor.authorKalkan, Sedat
dc.contributor.authorKilicgedik, Alev
dc.contributor.authorGuersoy, Mustafa Ozan
dc.contributor.authorOflar, Ersan
dc.date.accessioned2024-05-19T14:51:19Z
dc.date.available2024-05-19T14:51:19Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractBackgroundPapillary muscle free strain has not been evaluated previously in hypertrophic cardiomyopathy (HCMP) patients. Our aim was to evaluate free papillary muscle free strain in HCMP patients and to find whether it has a value for prediction of sudden cardiac death (SCD) risk score. MethodsTransthoracic echocardiography with tissue Doppler imaging, 2-D speckle tracking imaging (STI) of 55 HCMP patients and 45 controls were performed. HCMP patients were further divided into two groups according to their SCD risk score. Patients with risk score of less than 6 points constituted low/intermediate risk group, whereas patients with risk score of greater or equal to 6 points constituted high risk group. ResultsInterventricular septum, posterior wall, and left ventricular mass index were significantly higher, whereas mitral E/A ratio was significantly lower in HCMP patients compared to controls. Longitudinal apical 4C, 2C, 3C, global longitudinal LV strain, anterolateral papillary muscle (ALPM), posteromedial papillary muscle (PMPM) free strain were significantly reduced in HCMP group compared to control group. Global longitudinal strain and ALPM free strain were significantly lower in patients with high SCD risk score (-14.6 (-17.4 - -13.1) vs -11.6 (-13.2 - -10.1), p = 0.001 and -17.1 (-20.3 - -14.0) vs -9.2 (-12.6 - -7.5), p<0.001, respectively. Global longitudinal strain and ALPM free strain were statistically significantly correlated with SCD risk score (r = 0.480, p<0.001 and r = 0.462, p<0.001, respectively). Global longitudinal strain value of -12.60% had a sensitivity of 73.3% and specificity of 82.5% for predicting high SCD risk score (AUC: 0.787, 95% CI: 00.643-0.930, p = 0.001). ALPM free strain value of -12.95% had 66.7% sensitivity and 77.5% specificity for predicting high SCD risk score (AUC: 0.766, 95% CI: 0.626-0.905, p = 0.003). ConclusionPapillary muscle free strain was reduced in HCMP patients. It might be used in risk stratification of these patients.en_US
dc.identifier.doi10.1371/journal.pone.0282054
dc.identifier.issn1932-6203
dc.identifier.issue2en_US
dc.identifier.pmid36827304en_US
dc.identifier.scopus2-s2.0-85148861817en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org10.1371/journal.pone.0282054
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5918
dc.identifier.volume18en_US
dc.identifier.wosWOS:000972006100129en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPublic Library Scienceen_US
dc.relation.ispartofPlos Oneen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectCardiovascular Magnetic-Resonanceen_US
dc.subjectMyocardial Fibrosisen_US
dc.subjectSudden-Deathen_US
dc.subjectEchocardiographyen_US
dc.subjectQuantificationen_US
dc.subjectEnhancementen_US
dc.subjectSpectrumen_US
dc.subjectSocietyen_US
dc.subjectAshen_US
dc.titleDoes papillary muscle free strain has predictive value in risk stratification of patients with hypertrophic cardiomyopathy?en_US
dc.typeArticleen_US

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