Cardiovascular changes under the microgravity environment and the gut microbiome

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dc.authoridSiddiqui, Ruqaiyyah/0000-0001-9646-6208
dc.authoridKhan, Naveed/0000-0001-7667-8553
dc.authoridAltelly, Ahmad/0000-0001-5187-8284
dc.authorwosidSiddiqui, Ruqaiyyah/AIF-2100-2022
dc.authorwosidKhan, Naveed/AAM-2892-2021
dc.contributor.authorSiddiqui, Ruqaiyyah
dc.contributor.authorQaisar, Rizwan
dc.contributor.authorAl-Dahash, Khulood
dc.contributor.authorAltelly, Ahmad Hashem
dc.contributor.authorElmoselhi, Adel B.
dc.contributor.authorKhan, Naveed Ahmed
dc.date.accessioned2024-05-19T14:46:07Z
dc.date.available2024-05-19T14:46:07Z
dc.date.issued2024
dc.departmentİstinye Üniversitesien_US
dc.description.abstractIn view of the critical role the gut microbiome plays in human health, it has become clear that astronauts' gut microbiota composition changes after spending time in space. Astronauts are exposed to several risks in space, including a protracted period of microgravity, radiation, and mechanical unloading of the body. Several deleterious effects of such an environment are reported, including orthostatic intolerance, cardiovascular endothelial dysfunction, cellular and molecular changes, and changes in the composition of the gut microbiome. Herein, the correlation between the gut microbiome and cardiovascular disease in a microgravity environment is evaluated. Additionally, the relationship between orthostatic hypotension, cardiac shrinkage and arrhythmias during spaceflight, and cellular alterations during spaceflight is reviewed. Given its impact on human health in general, modifying the gut microbiota may significantly promote astronaut health and performance. This is merited, given the prospect of augmented human activities in future space missions.en_US
dc.description.sponsorshipAir Force Office of Scientific Research (AFOSR) , USAen_US
dc.description.sponsorshipRuqaiyyah Siddiqui and Naveed Ahmed Khan are supported by the Air Force Office of Scientific Research (AFOSR) , USA.en_US
dc.identifier.doi10.1016/j.lssr.2023.09.003
dc.identifier.endpage96en_US
dc.identifier.issn2214-5524
dc.identifier.issn2214-5532
dc.identifier.pmid38245353en_US
dc.identifier.scopus2-s2.0-85171679954en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage89en_US
dc.identifier.urihttps://doi.org10.1016/j.lssr.2023.09.003
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5447
dc.identifier.volume40en_US
dc.identifier.wosWOS:001169731400001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofLife Sciences In Space Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectOrthostatic Hypotensionen_US
dc.subjectGut Microbiomeen_US
dc.subjectCardiovascular Changesen_US
dc.subjectMicrogravityen_US
dc.subjectSpace Travelen_US
dc.titleCardiovascular changes under the microgravity environment and the gut microbiomeen_US
dc.typeReview Articleen_US

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