Serum kallistatin level is decreased in women with preeclampsia

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dc.authoridHuri Bulut / 0000-0003-2706-9625en_US
dc.authorscopusidHuri Bulut / 57185264300
dc.authorwosidHuri Bulut / AAM-1432-2020
dc.contributor.authorGüralp, Onur
dc.contributor.authorTüten, Nevin
dc.contributor.authorGök, Koray
dc.contributor.authorHamzaoğlu, Kübra
dc.contributor.authorBulut, Huri
dc.contributor.authorSchild-Suhren, Meike
dc.contributor.authorMalik, Eduard
dc.contributor.authorTüten, Abdullah
dc.date.accessioned2020-09-24T13:50:41Z
dc.date.available2020-09-24T13:50:41Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective To evaluate the serum levels of the serine proteinase inhibitor kallistatin in women with preeclampsia (PE). Methods The clinical and laboratory parameters of 55 consecutive women with early-onset PE (EOPE) and 55 consecutive women with late-onset PE (LOPE) were compared with 110 consecutive gestational age (GA)-matched (±1 week) pregnant women with an uncomplicated pregnancy and an appropriate for gestational age fetus. Results Mean serum kallistatin was significantly lower in women with PE compared to the GA-matched-controls (27.74±8.29 ng/mL vs. 37.86±20.64 ng/mL, p<0.001); in women with EOPE compared to that of women in the control group GA-matched for EOPE (24.85±6.65 ng/mL vs. 33.37±17.46 ng/mL, p=0.002); and in women with LOPE compared to that of women in the control group GA-matched for LOPE (30.87±8.81 ng/mL vs. 42.25±22.67 ng/mL, p=0.002). Mean serum kallistatin was significantly lower in women with EOPE compared to LOPE (24.85±6.65 ng/mL vs. 30.87±8.81 ng/mL, p<0.001). Serum kallistatin had negative correlations with systolic and diastolic blood pressure, creatinine, and positive correlation with GA at sampling and GA at birth. Conclusions Serum kallistatin levels are decreased in preeclamptic pregnancies compared to the GA-matched-controls. This decrease was also significant in women with EOPE compared to LOPE. Serum kallistatin had negative correlation with systolic and diastolic blood pressure, creatinine and positive correlation with GA at sampling and GA at birth.en_US
dc.identifier.citationGüralp, O., Tüten, N., Gök, K., Hamzaoglu, K., Bulut, H., Schild-Suhren, M., ... & Tüten, A. (2020). Serum kallistatin level is decreased in women with preeclampsia. Journal of Perinatal Medicine, 1(ahead-of-print).en_US
dc.identifier.doi10.1515/jpm-2020-0142en_US
dc.identifier.pmid32866127en_US
dc.identifier.scopus2-s2.0-85091882587en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1515/jpm-2020-0142
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1090
dc.identifier.wosWOS:000597289500010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBulut, Huri
dc.language.isoenen_US
dc.relation.ispartofJ Perinat Meden_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEarly-Onset Preeclampsiaen_US
dc.subjectHypertensionen_US
dc.subjectKallikrein Inhibitoren_US
dc.subjectNitric-Oxideen_US
dc.subjectSerpinA4en_US
dc.titleSerum kallistatin level is decreased in women with preeclampsiaen_US
dc.typeArticleen_US

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