Assessment of sacubitril/valsartan effects on left ventricular dynamics using 3D echocardiography and 3D strain in heart failure with reduced ejection fraction patients

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dc.authoridTuğba Kemaloğlu Öz / 0000-0003-1168-8237
dc.authorscopusidTuğba Kemaloğlu Öz / 55804564100
dc.authorwosidTuğba Kemaloğlu Öz / HXI-6000-2023
dc.contributor.authorKemaloğlu Öz, Tuğba
dc.contributor.authorAbdelnabi, Mahmoud
dc.contributor.authorFiore, Corrado
dc.contributor.authorAlmaghraby, Abdallah
dc.contributor.authorCihan, Deniz
dc.contributor.authorBabazade, Nigar
dc.date.accessioned2021-11-10T13:33:24Z
dc.date.available2021-11-10T13:33:24Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBACKGROUND: Three-dimensional (3D) echocardiography and 3D strain parameters have been used for a comprehensive quantitative assessment of left ventricular (LV) myocardial dynamics. So far, there are no data on sacubitril/valsartan effects on cardiac functions and LV reverse remodeling using 3D echocardiography. This study aimed to evaluate the effects of sacubitril/valsartan on the LV functions using two-dimensional (2D) echocardiography, 3D echocardiography, and the 3D strain parameters. METHODS: A single-center prospective cohort study which included 100 heart failure with reduced ejection fraction (HFrEF) patients with guidelines-approved indications for sacubitril/valsartan treatment. Patients received a short course (3-month) of sacubitril/valsartan. 3-month follow-up 2D, 3D echocardiographic parameters, and 3D strain were compared to baseline parameters. RESULTS: The results of the study revealed a significant improvement in left ventricular dynamic functions at 3-month follow-up with an improvement in left ventricular systolic function (mean left ventricular ejection fraction (LVEF) increased from 27.65 ± 4.98% to 32.89 ± 6.03%, P<0.001). Comparison of HFrEF patients with ischemic and non-ischemic etiologies showed that echocardiographic parameters significantly improved in both groups after 3 months of sacubitril/valsartan treatment. There was no statistically significant difference between both groups regarding echocardiographic parameters at baseline and 3-month follow-up. CONCLUSIONS: In a single-center prospective observational cohort study evaluating the effects of short-term (3-month course) sacubitril/valsartan treatment on LV dynamics assessed by 3D echocardiography and 3D strain, sacubitril/valsartan was associated with a significant improvement of LV systolic functions and reverse remodeling effects in both ischemic and non-ischemic HFrEF patients.en_US
dc.identifier.citationÖz, T. K., Abdelnabi, M., Fiore, C., Almaghraby, A., Cihan, D., Babazade, N., Haseeb Raza Naqvi, S., Omar, B., & Dağdeviren, B. (2021). Assessment of sacubitril/valsartan effects on left ventricular dynamics using 3D echocardiography and 3D strain in heart failure with reduced ejection fraction patients. Minerva cardiology and angiology, 10.23736/S2724-5683.21.05802-6. Advance online publication. https://doi.org/10.23736/S2724-5683.21.05802-6en_US
dc.identifier.doi10.23736/S2724-5683.21.05802-6en_US
dc.identifier.pmid34713680en_US
dc.identifier.scopus2-s2.0-85135419373en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.23736/S2724-5683.21.05802-6
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2215
dc.identifier.wosWOS:000968189300004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKemaloğlu Öz, Tuğba
dc.language.isoenen_US
dc.publisherMedGenen_US
dc.relation.ispartofMinerva Cardiology and Angiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHeart Failure With Reduced Ejection Fraction (HFrEF)en_US
dc.subjectSacubitril/valsartanen_US
dc.subject3D Echocardiographyen_US
dc.subject3D Stainen_US
dc.subjectVentricular Remodelingen_US
dc.titleAssessment of sacubitril/valsartan effects on left ventricular dynamics using 3D echocardiography and 3D strain in heart failure with reduced ejection fraction patientsen_US
dc.typeArticleen_US

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