Distribution of spleen connective tissue fibers in diabetic and vitamin C treated diabetic rats

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dc.authoridDilşad Özerkan / 0000-0002-0556-3879en_US
dc.authorscopusidDilşad Özerkan / 56805133700
dc.authorwosidDilşad Özerkan / AAC-3485-2021
dc.contributor.authorÖzerkan, Dilşaden_US
dc.contributor.authorÖzsoy, Nesrinen_US
dc.contributor.authorCebesoy, Sunaen_US
dc.contributor.authorÖzer, Çiğdemen_US
dc.date.accessioned2020-08-30T20:06:07Z
dc.date.available2020-08-30T20:06:07Z
dc.date.issued2020
dc.departmentİstinye Üniversitesi, Sağlık Bilimleri Fakültesi, Fizyoterapi ve Rehabilitasyon Bölümüen_US
dc.description.abstractWe investigated the distribution of connective tissue fibers in diabetic and vitamin C treated diabetic rat spleen. Rats were divided into three groups: group A, control; group B, diabetic; group C, vitamin C treated diabetic. Diabetes was induced by streptozotocin. Vitamin C was administered intragastrically for 21 days. Spleen tissues were examined by light microscopy after staining with Masson's trichrome, Gomori silver impregnation and van Gieson. In group B, we found accumulation of collagen fibers in the trabeculae, in the capsule and around the central artery and splenic sinusoids. Splenic cord thickening due to fibrosis was observed. Reticular fibers accumulated principally in the white and red pulps of the spleen and focal reticular fiber thickening was observed in the dense fiber areas. Partial elastic fiber rupture was observed among the fibers of the elastic lamina of the arteries in the hilum. By contrast, the distribution of collagen fibers in group C was similar to group A. Collagen fiber accumulation was decreased in group C compared to group B. We found little reticular fiber thickening in group C and elastic fibers maintained their integrity and were better organized than in group B. Our findings suggest thatappropriate doses of vitamin C may exert beneficial effects on the structure of the connective tissue fibers in the diabetic spleen.en_US
dc.identifier.citationÖzerkan, D., Özsoy, N., Cebesoy, S., & Özer, Ç. (2020). Distribution of spleen connective tissue fibers in diabetic and vitamin C treated diabetic rats. Biotechnic & Histochemistry, 1-7.en_US
dc.identifier.doi10.1080/10520295.2020.1795718en_US
dc.identifier.issn1052-0295en_US
dc.identifier.issn1473-7760en_US
dc.identifier.pmid32696689en_US
dc.identifier.scopus2-s2.0-85088376029en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2020.1795718
dc.identifier.urihttps://hdl.handle.net/20.500.12713/370
dc.identifier.wosWOS:000550951600001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÖzerkan, Dilşaden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectConnective Tissueen_US
dc.subjectDiabetesen_US
dc.subjectFibersen_US
dc.subjectSpleenen_US
dc.subjectVitamin Cen_US
dc.titleDistribution of spleen connective tissue fibers in diabetic and vitamin C treated diabetic ratsen_US
dc.typeArticleen_US

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