Epidemiologic and microbiologic evaluation of catheter-line bloodstream infection in a pediatric hematopoietic stem cell transplant center

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dc.authoridSutcu, Murat/0000-0002-2078-9796
dc.authoridGul, doruk/0000-0001-7151-4138
dc.authorwosidSutcu, Murat/AAR-5212-2020
dc.authorwosidBaşoğlu Öner, Özlem/JBI-7610-2023
dc.authorwosidBozkurt, Ceyhun/AAL-5043-2021
dc.contributor.authorAksoy, Basak A.
dc.contributor.authorKara, Manolya
dc.contributor.authorSutcu, Murat
dc.contributor.authorOzbek, Ahmet
dc.contributor.authorErsoy, Gizem Z.
dc.contributor.authorOner, Ozlem B.
dc.contributor.authorAydogdu, Selime
dc.date.accessioned2024-05-19T14:39:54Z
dc.date.available2024-05-19T14:39:54Z
dc.date.issued2024
dc.departmentİstinye Üniversitesien_US
dc.description.abstractBackground: Children who underwent hematopoietic stem cell transplant (HSCT) transplants are at high risk of developing central-line-associated bloodstream infections (CLABSIs). The present study aimed to identify possible risk factors for mortality by analyzing the clinical and laboratory characteristics of patients diagnosed with CLABSI in our pediatric hematopoietic stem cell transplant unit.Methods: The initial CLABSI episodes of 102 children were analyzed. Medical records of the patients were evaluated by preformed standardized surveys. Univariate analysis and multivariate logistic regression analysis were performed to identify risk factors for mortality.Results: Thirty-five patients (34.3%) were female. The median age was 48 months (3-204). The median time to onset of CLABSI was 19 days (4-150). The gram-negative and gram-positive bacteria ratio among the causative agents was 57.8% to 34.3%. The mortality rate was 12.6%. The presence of severe neutropenia, initiation of inappropriate empirical antibiotic therapy, the presence of hypotension, persistent bacteremia, pediatric intensive care unit admission, growth of carbapenemase-positive gram-negative microorganism and multidrug-resistant bacteria were significantly high in the mortality group when compared to survivors. The presence of hypotension, inappropriate empirical antibiotic therapy, and persistent bacteremia were found to be independent risk factors for mortality.Conclusions: Rational use of antibiotics, active surveillance and screening of patients together with improved infection control practices may reduce the incidence and the consequences of CLABSIs.(c) 2023 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.ajic.2023.08.010
dc.identifier.endpage86en_US
dc.identifier.issn0196-6553
dc.identifier.issn1527-3296
dc.identifier.issue1en_US
dc.identifier.pmid37591312en_US
dc.identifier.scopus2-s2.0-85173185534en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage81en_US
dc.identifier.urihttps://doi.org10.1016/j.ajic.2023.08.010
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4869
dc.identifier.volume52en_US
dc.identifier.wosWOS:001142892900001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMosby-Elsevieren_US
dc.relation.ispartofAmerican Journal of Infection Controlen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectCentral Venous Catheteren_US
dc.subjectPediatric Canceren_US
dc.subjectInfectious Complicaitonen_US
dc.titleEpidemiologic and microbiologic evaluation of catheter-line bloodstream infection in a pediatric hematopoietic stem cell transplant centeren_US
dc.typeArticleen_US

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