SCARB1 gene polymorphisms and HDL subfractions in coronary artery disease

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dc.authoridUzay Görmüş / 0000-0002-3124-0184
dc.authorscopusidUzay Görmüş / 16230182400
dc.authorwosidUzay Görmüş / JKU-7676-2023
dc.contributor.authorAyhan, Hüseyin
dc.contributor.authorGörmüş, Uzay
dc.contributor.authorİşbir, Selim
dc.contributor.authorYılmaz, Seda Güleç
dc.contributor.authorİşbir, Turgay
dc.date.accessioned2020-08-30T20:08:04Z
dc.date.available2020-08-30T20:08:04Z
dc.date.issued2017
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground/Aim: Cardiovascular diseases are a leading cause of mortality and morbidity worldwide. Polymorphisms in the SCARB1 gene are known to be related to plasma lipids. Patients and Methods: Real time-polymerase chain reaction (RT-PCR) was used for identification of SCARB1 polymorphisms and the Lipoprint Quantimetrix System was employed in identification of HDL subfractions. Results: According to allelic distribution, in both groups SCARB1 AA genotype led to a two-fold decrease in the risk of developing cardiovascular disease (p=0.04), while the GA genotype increased the risk two-fold (p=0.03). According to the HDL subfraction analysis results, the AA genotype had higher levels of big-sized HDL subfraction (p=0.02). Conclusion: The SCARB1AA genotype decreased cardiovascular risk and carrying GA genotype and G allele increased the risk of CAD. AA genotype carriers had higher levels of big-sized HDL subfraction.en_US
dc.identifier.citationAyhan, H., Gormus, U., Isbir, S., Yilmaz, S. G., & Isbir, T. (2017). SCARB1 gene polymorphisms and HDL subfractions in coronary artery disease. In Vivo, 31(5), 873–876. https://doi.org/10.21873/invivo.11141en_US
dc.identifier.doi10.21873/invivo.11141en_US
dc.identifier.endpage876en_US
dc.identifier.issn0258-851Xen_US
dc.identifier.issn1791-7549en_US
dc.identifier.issue5en_US
dc.identifier.pmid28882953en_US
dc.identifier.scopus2-s2.0-85029522559en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage873en_US
dc.identifier.urihttps://doi.org/10.21873/invivo.11141
dc.identifier.urihttps://hdl.handle.net/20.500.12713/880
dc.identifier.volume31en_US
dc.identifier.wosWOS:000414311600011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGörmüş, Uzayen_US
dc.language.isoenen_US
dc.publisherInt Inst Anticancer Researchen_US
dc.relation.ispartofIn Vivoen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCoronary Artery Diseaseen_US
dc.subjectHdl Subfractionsen_US
dc.subjectScarb1en_US
dc.subjectPolymorphismen_US
dc.titleSCARB1 gene polymorphisms and HDL subfractions in coronary artery diseaseen_US
dc.typeArticleen_US

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