Contribution of Autophagy to Epithelial Mesenchymal Transition Induction during Cancer Progression

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dc.authoridKhosravi, Arezoo/0009-0006-6654-4133
dc.authoridCordani, Marco/0000-0001-9342-4862
dc.authoridAllameh, Abdolamir/0000-0003-0757-9572
dc.authoridZarrabi, Ali/0000-0003-0391-1769
dc.authoridStrippoli, Raffaele/0000-0003-3483-8381
dc.authorwosidKhosravi, Arezoo/JFK-3987-2023
dc.authorwosidCordani, Marco/ABF-4669-2021
dc.authorwosidAllameh, Abdolamir/E-3177-2010
dc.authorwosidZarrabi, Ali/U-2602-2019
dc.authorwosidStrippoli, Raffaele/J-2129-2018
dc.contributor.authorStrippoli, Raffaele
dc.contributor.authorNiayesh-Mehr, Reyhaneh
dc.contributor.authorAdelipour, Maryam
dc.contributor.authorKhosravi, Arezoo
dc.contributor.authorCordani, Marco
dc.contributor.authorZarrabi, Ali
dc.contributor.authorAllameh, Abdolamir
dc.date.accessioned2024-05-19T14:39:13Z
dc.date.available2024-05-19T14:39:13Z
dc.date.issued2024
dc.departmentİstinye Üniversitesien_US
dc.description.abstractSimple Summary This manuscript focuses on the complex relationships between autophagy and epithelial mesenchymal transition (EMT) in cancer. Autophagy, a cellular degradation process, and EMT, a mechanism where epithelial cells acquire mesenchymal features, both play significant roles in cancer development. This review aims to explore how these processes interact, particularly how autophagy impacts cancer cell fate during EMT. The findings from this study are expected to contribute to a better understanding of cancer biology and could potentially impact cancer treatment strategies, as both autophagy and EMT are considered targets for therapy.Abstract Epithelial Mesenchymal Transition (EMT) is a dedifferentiation process implicated in many physio-pathological conditions including tumor transformation. EMT is regulated by several extracellular mediators and under certain conditions it can be reversible. Autophagy is a conserved catabolic process in which intracellular components such as protein/DNA aggregates and abnormal organelles are degraded in specific lysosomes. In cancer, autophagy plays a controversial role, acting in different conditions as both a tumor suppressor and a tumor-promoting mechanism. Experimental evidence shows that deep interrelations exist between EMT and autophagy-related pathways. Although this interplay has already been analyzed in previous studies, understanding mechanisms and the translational implications of autophagy/EMT need further study. The role of autophagy in EMT is not limited to morphological changes, but activation of autophagy could be important to DNA repair/damage system, cell adhesion molecules, and cell proliferation and differentiation processes. Based on this, both autophagy and EMT and related pathways are now considered as targets for cancer therapy. In this review article, the contribution of autophagy to EMT and progression of cancer is discussed. This article also describes the multiple connections between EMT and autophagy and their implication in cancer treatment.en_US
dc.description.sponsorshipThe Elite Research Committee of the NIMAD (National Institute for Medical Research Development)en_US
dc.description.sponsorshipNo Statement Availableen_US
dc.identifier.doi10.3390/cancers16040807
dc.identifier.issn2072-6694
dc.identifier.issue4en_US
dc.identifier.pmid38398197en_US
dc.identifier.scopus2-s2.0-85185907914en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org10.3390/cancers16040807
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4731
dc.identifier.volume16en_US
dc.identifier.wosWOS:001168344700001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofCancersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectAutophagyen_US
dc.subjectEpithelial Mesenchymal Transitionen_US
dc.subjectCell Deathen_US
dc.subjectCell Adhesion Moleculesen_US
dc.subjectCell Proliferationen_US
dc.subjectDifferentiationen_US
dc.titleContribution of Autophagy to Epithelial Mesenchymal Transition Induction during Cancer Progressionen_US
dc.typeReview Articleen_US

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