Effects of hydrogen sulfide on relaxation responses in the lower esophageal sphincter in rabbits: the potential role of potassium channels

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dc.authoridKara, Halil/0000-0002-7557-7897
dc.authoridKOÇ, AYŞEGÜL/0000-0002-8877-1373
dc.authoridOzturk Fincan, Gokce Sevim/0000-0003-1633-3320
dc.authorwosidKara, Halil/GWD-0681-2022
dc.authorwosidKOÇ, AYŞEGÜL/HDM-7044-2022
dc.contributor.authorKoc, Aysegul
dc.contributor.authorKoc, Derya Sebile
dc.contributor.authorAskin, Celil Ilker
dc.contributor.authorKara, Halil
dc.contributor.authorFincan, Gokce Sevim Ozturk
dc.contributor.authorIlhan, Sevil Ozger
dc.contributor.authorSarioglu, Yusuf
dc.date.accessioned2024-05-19T14:42:34Z
dc.date.available2024-05-19T14:42:34Z
dc.date.issued2024
dc.departmentİstinye Üniversitesien_US
dc.description19th World Congress of Basic and Clinical Pharmacology (WCP) -- JUL 02-07, 2023 -- Glasgow, SCOTLANDen_US
dc.description.abstractHydrogen sulfide (H2S) is a significant physiologic inhibitory neurotransmitter. The main goal of this research was to examine the contribution of diverse potassium (K+) channels and nitric oxide (NO) in mediating the H2S effect on electrical field stimulation (EFS)-induced neurogenic contractile responses in the lower esophageal sphincter (LES). EFS-induced contractile responses of rabbit isolated LES strips were recorded using force transducers in organ baths that contain Krebs-Henseleit solutions (20 ml). Cumulative doses of NaHS, L-cysteine, PAG, and AOAA were evaluated in NO-dependent and NO-independent groups. The experiments were conducted again in the presence of K+ channel blockers. In both NO-dependent and NO-independent groups, NaHS, L-cysteine, PAG, and AOAA significantly reduced EFS-induced contractile responses. In the NO-dependent group, the effect of NaHS and L-cysteine decreased in the presence of 4-AP, and also the effect of NaHS decreased in the NO-dependent and independent group in the presence of TEA. In the NO-independent group, K+ channel blockers didn't change L-cysteine-induced relaxations. K+ channel blockers had no impact on the effects of PAG and AOAA. In addition, NaHS significantly relaxed 80-mM KCl-induced contractions, whereas L-cysteine, PAG, and AOAA did not. In the present study, H2S decreased the amplitudes of EFS-induced contraction responses. These results suggest that Kv channels and NO significantly contribute to exogenous H2S and endogenous H2S precursor L-cysteine inhibitory effect on lower esophageal sphincter smooth muscle.en_US
dc.description.sponsorshipAnkara Yimath;ldimath;rimath;m Beyazimath;t niversitesien_US
dc.description.sponsorshipNo Statement Availableen_US
dc.identifier.doi10.1007/s00210-023-02695-z
dc.identifier.endpage1550en_US
dc.identifier.issn0028-1298
dc.identifier.issn1432-1912
dc.identifier.issue3en_US
dc.identifier.pmid37668686en_US
dc.identifier.scopus2-s2.0-85169804796en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1537en_US
dc.identifier.urihttps://doi.org10.1007/s00210-023-02695-z
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5256
dc.identifier.volume397en_US
dc.identifier.wosWOS:001058956500002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofNaunyn-Schmiedebergs Archives of Pharmacologyen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectHydrogen Sulfideen_US
dc.subjectL-Cysteineen_US
dc.subjectPotassium Channelsen_US
dc.subjectNitric Oxideen_US
dc.subjectLower Esophageal Sphincteren_US
dc.subjectSmooth Muscleen_US
dc.titleEffects of hydrogen sulfide on relaxation responses in the lower esophageal sphincter in rabbits: the potential role of potassium channelsen_US
dc.typeConference Objecten_US

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