Does inflammation play a pole in the pathophysiology of tinnitus?

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dc.authoridMeltem Demir / 0000-0002-0836-8585en_US
dc.authorscopusidMeltem Demir / 56689396100
dc.authorwosidMeltem Demir / ERD-5630-2022
dc.contributor.authorDemir, Meltem
dc.date.accessioned2021-02-22T10:22:26Z
dc.date.available2021-02-22T10:22:26Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: The present study aimed to investigate the potential of neutrophil/ lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and mean platelet volume (MPV) as prognostic markers in tinnitus patients at inflammatory process. Methods:This study consisted of 216 subjects (124 males and 92 females), Routine laboratory CBC test results were calculated in this study. All the patients were divided into three groups according to their hearing thresholds: a high frequency hearing loss?tinnitus group (HFHL?TN) consisted of 55 subjects, an hearing loss in all frequencies tinnitus group (AFHL?TN) consisted of 53 subjects and a normal hearing?tinnitus group (NH?TN) consisted of 51 subjects. The control group (CNT) included 57 age?and sex?matched healthy subjects. Results: NLR, PLR and MPV were observed in the HFHL?TN group when compared to AFHL? TN, NH?TN and CNT group (P < 0.001). An increase in NLR was observed in the AFHL?TN group compared with the CNT group (P = 0.004). The PLR value of the HFHL?TN group was significantly higher than that of the AFHL?TN (P = 0.028) and NH?TN,CNTgroup (P < 0001). The PLR value of the HFHL?TN group was significantly higher than that of the AFHL?TN (p=0.028) and NH?TN, CNT group (P < 0001). MPV values in HFHL?TN group was slightly higher AFHL?TN group and significantly higher than NH?TN (P = 0.025) and CNT (P < 0.001) group. Conclusion: Our results confirm that elevated NLR, PLR and MPV values has been suggested to be a useful inflammatuar prognostic biomarker of tinnitus patients.en_US
dc.identifier.citationDemir M. (2021). Does inflammation play a role in the pathophysiology of tinnitus?. Nigerian journal of clinical practice, 24(2), 199–204. https://doi.org/10.4103/njcp.njcp_381_19en_US
dc.identifier.doi10.4103/njcp.njcp_381_19en_US
dc.identifier.endpage204en_US
dc.identifier.issue2en_US
dc.identifier.pmid33605909en_US
dc.identifier.scopus2-s2.0-85101975253en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage2199en_US
dc.identifier.urihttps://doi.org/10.4103/njcp.njcp_381_19
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1485
dc.identifier.volume24en_US
dc.identifier.wosWOS:000623686500009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorDemir, Meltem
dc.language.isoenen_US
dc.relation.ispartofNiger J Clin Pract.en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMean Platelet Volumeen_US
dc.subjectNeutrophil-to-lymphocyte Ratioen_US
dc.subjectPlatelet-to-lymphocyte Ratioen_US
dc.subjectTinnitusen_US
dc.titleDoes inflammation play a pole in the pathophysiology of tinnitus?en_US
dc.typeArticleen_US

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