Is microcystic, elongated, and fragmented pattern of myometrial invasion in endometrioid endometrial carcinoma associated with survival?

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dc.authoridSerhat Şen / 0000-0002-2215-0662en_US
dc.authorscopusidSerhat Şen / 45761371100en_US
dc.authorwosidSerhat Şen / DWV-0794-2022
dc.contributor.authorAltındağ, Sultan Deniz
dc.contributor.authorYiğit, Seyran
dc.contributor.authorŞen, Serhat
dc.date.accessioned2022-11-14T11:30:12Z
dc.date.available2022-11-14T11:30:12Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground/aim: Microcystic, elongated, and fragmented (MELF) pattern is one of the myometrial invasion patterns in endometrioid endometrial carcinoma (EEC), and it has been associated with poor prognostic parameters, especially lymphovascular space invasion (LVSI) and lymph node metastasis (LNM). This study aims to represent the frequency of MELF pattern in EEC and the relationship between MELF pattern with clinicopathological parameters, overall survival (OS), and disease-free survival (DFS). Materials and methods: In this retrospective cohort study, we examined 233 patients with EEC diagnoses with the result of a total hysterectomy and bilateral salpingo-oophorectomy between 2009 and 2014. The association of MELF pattern with risk factors such as stage, recurrence, and survival was analysed statistically with the comparison of MELF positive and negative cases. Results: MELF pattern was seen in 21.8% of all cases (51/233) and 23% of grade 1-2 cases (50/217). The MELF pattern showed a significant difference among patients when they were compared according to advanced age (?60) (p = 0.022), LVSI (p = 0.021), deep myometrial invasion (p < 0.01), LNM (p = 0.027), and advanced FIGO stage (p = 0.043). MELF pattern was a predictive factor of LNM in univariate logistic regression analysis but did not show significance in multivariate analysis. The Kaplan–Meier survival analysis showed that MELF positive cases had reduced OS (66.7% vs 79.7% p = 0.003) and DFS (66.7% vs 77.5% p = 0.017) rates. In the univariate analyses, MELF pattern was an independent prognostic factor on OS and DFS along with other parameters, while it was not observed to maintain this effect in the multivariate analyses. Conclusion: This study is one of the largest series examining the relationship between MELF pattern of myometrial invasion and survival, and our results represented that the MELF pattern is associated with the worse clinical outcome since it is associated with lymphovascular space invasion, deep myometrial invasion, lymph node metastasis, and reduced overall survival and disease-free survival rates. Although the presence of MELF pattern is not reported in routine practice, it may be used as an indicator that will help predict a worse outcome. © 2022, Turkiye Klinikleri. All rights reserved.en_US
dc.identifier.citationAltindağ, S. D., Yiğit, S., & Şen, S. (2022). Is microcystic, elongated, and fragmented pattern of myometrial invasion in endometrioid endometrial carcinoma associated with survival? Turkish Journal of Medical Sciences, 52(5), 1569-1579. doi:10.55730/1300-0144.5497en_US
dc.identifier.doi10.55730/1300-0144.5497en_US
dc.identifier.endpage1579en_US
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85140308329en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1596en_US
dc.identifier.urihttps://doi.org/10.55730/1300-0144.5497
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3381
dc.identifier.volume52en_US
dc.identifier.wosWOS:000890907200017en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorŞen, Serhat
dc.language.isoenen_US
dc.publisherTurkiye Kliniklerien_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEndometrioid Endometrial Carcinomaen_US
dc.subjectlymph Node Metastasisen_US
dc.subjectYmphovascular Space Invasionen_US
dc.subjectMELF Patternen_US
dc.subjectMyometrial Invasionen_US
dc.subjectSurvivalen_US
dc.titleIs microcystic, elongated, and fragmented pattern of myometrial invasion in endometrioid endometrial carcinoma associated with survival?en_US
dc.typeArticleen_US

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