Age-related changes in the immunomodulatory effects of human dental pulp derived mesenchymal stem cells on the CD4 + T cell subsets

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dc.authoridErdal Karaöz / 0000-0002-9992-833Xen_US
dc.authorscopusidErdal Karaöz / 7003448087
dc.authorwosidErdal Karaöz / IXE-6677-2023
dc.contributor.authorÖzdemir, Rabia Bilge Özgül
dc.contributor.authorÖzdemir, Alper Tunga
dc.contributor.authorKırmaz, Cengiz
dc.contributor.authorSarıboyacı, Ayla Eker
dc.contributor.authorKaraöz, Erdal
dc.contributor.authorErman, Gülay
dc.contributor.authorVatansever, H. Seda
dc.contributor.authorGökmen, Nihal Mete
dc.date.accessioned2020-11-24T09:49:44Z
dc.date.available2020-11-24T09:49:44Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractMesenchymal stem cells (MSCs) are powerful immunomodulatory cells. The effects of the aging on these abilities of MSCs have not been adequately clarified. In this study, alterations in immunomodulatory abilities of MSCs caused by aging were investigated. For this, dental pulp (DP) MSCs and peripheral blood mononuclear cells (PBMCs) of elderly and young donors were co-cultured age-matched and cross. We detected that the effects of DP-MSCs on Th1 and Th2 cells and their specific cytokines IFN-? and IL-4 are not affected by aging. However, we observed that young and elderly DP-MSCs have different effects on Th17 and Treg cells. Th17 frequencies of young and elderly PBMCs were significantly increased only by young DP-MSCs, in contrast, Treg frequencies were significantly increased by elderly DP-MSCs. IL-6, IL-17a and HGF levels of both young and elderly PBMCs showed a significant increase only by young DP-MSCs, but TGF-? levels were significantly increased only by elderly DP-MSCs. The oral cavity is home to a rich microflora. The interactions of dental tissues with this microflora can lead them to acquire different epigenetic modifications. Aging can affect the microflora composition of the oral cavity and change this process in different directions. According to our findings, DP-MSCs are effective cells in the regulation of CD4+ T cells, and their effects on Th1 and Th2 cells were not affected by aging. However, pleiotropic molecules IL-6 and HGF expressions, which are important in dental and bone tissue regeneration, decreased significantly in elderly DP-MSCs. This situation may have indirectly made a difference in the modulation effects of young and elderly DP-MSCs on the Th17 and Treg cells.en_US
dc.identifier.citationÖzgül Özdemir, R. B., Özdemir, A. T., Kırmaz, C., Eker Sarıboyacı, A., Karaöz, E., Erman, G., Vatansever, H. S., & Mete Gökmen, N. (2020). Age-related changes in the immunomodulatory effects of human dental pulp derived mesenchymal stem cells on the CD4+ T cell subsets. Cytokine, 155367. Advance online publication. https://doi.org/10.1016/j.cyto.2020.155367en_US
dc.identifier.doi10.1016/j.cyto.2020.155367en_US
dc.identifier.issn1043-4666en_US
dc.identifier.pmid33223447en_US
dc.identifier.scopus2-s2.0-85096896765en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.cyto.2020.155367
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1252
dc.identifier.wosWOS:000612690900012en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKaraöz, Erdal
dc.language.isoenen_US
dc.relation.ispartofCytokineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAgingen_US
dc.subjectCD4 T Cellen_US
dc.subjectDental Pulpen_US
dc.subjectImmunomodulationen_US
dc.subjectMesenchymal Stem Cellen_US
dc.titleAge-related changes in the immunomodulatory effects of human dental pulp derived mesenchymal stem cells on the CD4 + T cell subsetsen_US
dc.typeArticleen_US

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