Antibacterial, antioxidant, and healing potential of wound dressings utilizing cranberry extract in combination with methacrylated polyvinyl alcohol and methacrylated sericin

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dc.authorscopusidGülşah Torkay / 57753937500
dc.authorscopusidAyça Bal Öztürk / 57062000100
dc.authorwosidGülşah Torkay / IUP-3797-2023
dc.authorwosidAyça Bal Öztürk / KRG-6786-2024
dc.contributor.authorÖzkahraman, Bengi
dc.contributor.authorTorkay, Gülşah
dc.contributor.authorİdil, Neslihan
dc.contributor.authorÖzbaş, Zehra
dc.contributor.authorBal Öztürk, Ayça
dc.date.accessioned2025-04-18T09:58:25Z
dc.date.available2025-04-18T09:58:25Z
dc.date.issued2024
dc.departmentİstinye Üniversitesi, Lisansüstü Eğitim Enstitüsü, Sağlık Bilimleri, Kök Hücre ve Doku Mühendisliği Programı
dc.description.abstractPurposeHydrogels, due to their hydrophilic nature and tunable properties, have emerged as promising materials for wound dressings. Notably, the ability to incorporate antibacterial and antioxidant agents into hydrogels offers significant advantages in reducing bacterial colonization, scavenging reactive oxygen species (ROS), mitigating inflammation, and accelerating wound closure. This study investigated the potential of cranberry extract (CR)-incorporated poly(vinyl alcohol)/silk sericin (PVAMA/SERMA) hydrogel wound dressings to promote effective antimicrobial activity and wound healing.MethodsMethacrylated poly(vinyl alcohol) (PVAMA) and silk sericin (SERMA) pre-polymers were synthesized. The wound dressings consisting of PVAMA, SERMA, and CR were fabricated by photopolymerization method. The chemical and thermal structures of wound dressings were investigated by FTIR and TGA analysis. The assessment of the physical characteristics was conducted through the analysis of swelling and in vitro degradation tests. The effect of various concentrations of CR in wound dressings on cytotoxicity and healing performance of NIH/3T3 fibroblast cell line was examined using extract-based MTT and scratch assays, respectively. Antibacterial and antioxidant properties of the wound dressing were performed against Escherichia coli and Staphylococcus aureus aureus using the agar diffusion method and DPPH assay, respectively.ResultsThe findings suggest that CR-loaded PVAMA/SERMA hydrogels hold promise as novel wound dressing materials due to their enhanced antibacterial, antioxidant, and wound healing capabilities, potentially accelerating wound recovery.Lay SummaryHydrogels, due to their hydrophilic nature, tunable chemical, mechanical, and biological properties, have shown great promises for wound dressing application. Notably, antibacterial and antioxidant hydrogels reduce bacterial colonization and infection, scavenge ROS, relieve inflammation, and accelerate wound healing. In this study, The PVAMA/SERMA-based wound dressings with various concentrations of CR (0, 1, and 2 wt % of polymer) were prepared by the photopolymerization method to achieve effective antimicrobial and wound healing potential.
dc.identifier.citationÖzkahraman, B., Torkay, G., İdil, N., Özbaş, Z., & Bal-Öztürk, A. (2024). Antibacterial, Antioxidant, and Healing Potential of Wound Dressings Utilizing Cranberry Extract in Combination with Methacrylated Polyvinyl Alcohol and Methacrylated Sericin. Regenerative Engineering and Translational Medicine, 1-13.
dc.identifier.doi10.1007/s40883-024-00346-0
dc.identifier.issn2364-4133
dc.identifier.issn2364-4141
dc.identifier.scopus2-s2.0-85197768164
dc.identifier.scopusqualityQ2
dc.identifier.urihttp://dx.doi.org/10.1007/s40883-024-00346-0
dc.identifier.urihttps://hdl.handle.net/20.500.12713/6904
dc.identifier.wosWOS:001265173400001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorTorkay, Gülşah
dc.institutionauthorBal Öztürk, Ayça
dc.institutionauthoridGülşah Torkay / 0000-0002-6803-494X
dc.institutionauthoridAyça Bal Öztürk / 0000-0002-6502-528X
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofRegenerative engineering and translational medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.relation.tubitak1649B022101483
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectSilk Sericin
dc.subjectCranberry Extract
dc.subjectWound Dressing
dc.subjectAntibacterial and Antioxidant Activity
dc.subjectIn Vitro Scratch Assay
dc.titleAntibacterial, antioxidant, and healing potential of wound dressings utilizing cranberry extract in combination with methacrylated polyvinyl alcohol and methacrylated sericin
dc.typeArticle

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