Potential anti-amoebic activity of sulfonate- and sulfamate-containing carboxamide derivatives against pathogenic Acanthamoeba castellanii belonging to the genotype T4

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dc.authoridKhan, Naveed/0000-0001-7667-8553
dc.authoridSiddiqui, Ruqaiyyah/0000-0001-9646-6208
dc.authoridZareei, Seyed Omar/0000-0002-0212-2146
dc.authoridAkbar, Noor/0000-0002-8114-1969
dc.authorwosidKhan, Naveed/AAM-2892-2021
dc.authorwosidKhan, Naveed/KCK-0156-2024
dc.authorwosidSiddiqui, Ruqaiyyah/AIF-2100-2022
dc.authorwosidAlawfi, Bader/JSK-2052-2023
dc.contributor.authorAkbar, Noor
dc.contributor.authorSiddiqui, Ruqaiyyah
dc.contributor.authorEl-Gamal, Mohammed I.
dc.contributor.authorZaraei, Seyed-Omar
dc.contributor.authorSaeed, Balsam Qubais
dc.contributor.authorAlawfi, Bader Saleem
dc.contributor.authorKhan, Naveed Ahmed
dc.date.accessioned2024-05-19T14:38:46Z
dc.date.available2024-05-19T14:38:46Z
dc.date.issued2024
dc.departmentİstinye Üniversitesien_US
dc.description.abstractAcanthamoeba are ubiquitously distributed in the environment and can cause infection of the central nervous system as well a sight-threatening eye infection. Herein, the potential anti-amoebic activity of a series of sulfonate/sulfamate derivatives against pathogenic A. castellanii was evaluated. These compounds were tested using several assays namely amoebicidal, adhesion, excystation, cytotoxic, and cytopathogenicity. Amoebicidal assays revealed that the selected compounds reduced amoebae viability significantly (P < 0.05), and exhibited IC50 values at two-digit micromolar concentrations. Sulfamate derivatives 1j & 1k inhibited 50% of amoebae at 30.65 mu M and 27.21 mu M, respectively. The tested compounds blocked amoebae binding to host cells as well as inhibited amoebae excystation. Notably, the selected derivatives exhibited minimal human cell cytotoxicity but reduced parasite-mediated host cell damage. Overall, our study showed that sulfamate derivatives 1j & 1k have anti-amoebic potential and offer a promising avenue in the development of potential anti-amoebic drug candidates.en_US
dc.description.sponsorshipAir Force Office of Scientific Research (AFOSR) , USAen_US
dc.description.sponsorshipRuqaiyyah Siddiqui and Naveed Ahmed Khan are supported by the Air Force Office of Scientific Research (AFOSR) , USA.en_US
dc.identifier.doi10.1016/j.parint.2023.102814
dc.identifier.issn1383-5769
dc.identifier.issn1873-0329
dc.identifier.pmid37806551en_US
dc.identifier.scopus2-s2.0-85173763880en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org10.1016/j.parint.2023.102814
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4602
dc.identifier.volume98en_US
dc.identifier.wosWOS:001102987900001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofParasitology Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectAcanthamoeba Castellaniien_US
dc.subjectSulfamateen_US
dc.subjectSulfonateen_US
dc.subjectAmoebicidalen_US
dc.subjectCytotoxicityen_US
dc.subjectCytopathogenicityen_US
dc.titlePotential anti-amoebic activity of sulfonate- and sulfamate-containing carboxamide derivatives against pathogenic Acanthamoeba castellanii belonging to the genotype T4en_US
dc.typeArticleen_US

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