Reduced antioxidant capacity in children with iron deficiency and iron-deficiency anemia
Küçük Resim Yok
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: This study aimed to assess the relationship between antioxidant enzymes such as glutathione peroxidase (GSH-Px), glutathione reductase (GSH-R), and paraoxonase (PON1) and carotid intima-media thickness (CIMT) and investigate susceptibility to atherosclerosis with decreasing antioxidant capacity in adolescent patients with iron deficiency (ID) and irondeficiency anemia (IDA). Material and methods: Twenty-five patients with IDA (14.9±1.8 years; 14 female and 11 male patients), 25 patients with ID (14.1±2.24 years; 13 female and 12 male patients) and 21 healthy controls (14.04±2.01 years; 11 female and 10 male individuals) were included in the study. Serum PON1, GSH-Px, GSH-R, and CIMT were measured in all cases. After 3-month oral iron therapy for the group with IDA, the same measurements were performed again. Results: CIMT was statistically significantly higher in patients with ID and IDA than in the control group (p<0.05). PON1, GSH-Px, and GSH-R activities decreased and were statistically significantly low in patients with IDA compared to the control group (p<0.05). Serum PON1 activity was statistically significantly lower in patients with ID than in the control group (p<0.05). Post-treatment PON1, GSH-Px, and GSH-R activities in patients with IDA got back to normal and were statistically significantly higher compared to pre-treatment values. Conclusions: Antioxidant capacity decreases in patients with IDA and ID, which causes atherosclerotic changes. Therefore, patients with iron deficiency must be treated without the development of iron-deficiency anemia.
Açıklama
Anahtar Kelimeler
Antioxidant Capacity, Iron Deficiency, Iron-deficiency Anemia, Carotid Intimamedia Thickness
Kaynak
Minerva Pediatrics
WoS Q Değeri
Q3
Scopus Q Değeri
Cilt
Sayı
Künye
Aslaner, H., Dündar, M. A., Arslan, A., Karakükcü, Ç., & Altuner Torun, Y. (2021). Reduced antioxidant capacity in children with iron deficiency and iron-deficiency anemia. Minerva pediatrics, 10.23736/S2724-5276.21.06193-4. Advance online publication. https://doi.org/10.23736/S2724-5276.21.06193-4
