Reduced antioxidant capacity in children with iron deficiency and iron-deficiency anemia

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dc.authoridYasemin Altuner Torun / 0000-0002-9860-8596en_US
dc.authorscopusidYasemin Altuner Torun / 56615130500
dc.contributor.authorAslaner, Humeyra
dc.contributor.authorDundar, Mehmet Akif
dc.contributor.authorArslan, Alev
dc.contributor.authorKarakukcu, Cigdem
dc.contributor.authorAltuner Torun, Yasemin
dc.date.accessioned2021-04-19T09:59:12Z
dc.date.available2021-04-19T09:59:12Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: This study aimed to assess the relationship between antioxidant enzymes such as glutathione peroxidase (GSH-Px), glutathione reductase (GSH-R), and paraoxonase (PON1) and carotid intima-media thickness (CIMT) and investigate susceptibility to atherosclerosis with decreasing antioxidant capacity in adolescent patients with iron deficiency (ID) and irondeficiency anemia (IDA). Material and methods: Twenty-five patients with IDA (14.9±1.8 years; 14 female and 11 male patients), 25 patients with ID (14.1±2.24 years; 13 female and 12 male patients) and 21 healthy controls (14.04±2.01 years; 11 female and 10 male individuals) were included in the study. Serum PON1, GSH-Px, GSH-R, and CIMT were measured in all cases. After 3-month oral iron therapy for the group with IDA, the same measurements were performed again. Results: CIMT was statistically significantly higher in patients with ID and IDA than in the control group (p<0.05). PON1, GSH-Px, and GSH-R activities decreased and were statistically significantly low in patients with IDA compared to the control group (p<0.05). Serum PON1 activity was statistically significantly lower in patients with ID than in the control group (p<0.05). Post-treatment PON1, GSH-Px, and GSH-R activities in patients with IDA got back to normal and were statistically significantly higher compared to pre-treatment values. Conclusions: Antioxidant capacity decreases in patients with IDA and ID, which causes atherosclerotic changes. Therefore, patients with iron deficiency must be treated without the development of iron-deficiency anemia.en_US
dc.identifier.citationAslaner, H., Dündar, M. A., Arslan, A., Karakükcü, Ç., & Altuner Torun, Y. (2021). Reduced antioxidant capacity in children with iron deficiency and iron-deficiency anemia. Minerva pediatrics, 10.23736/S2724-5276.21.06193-4. Advance online publication. https://doi.org/10.23736/S2724-5276.21.06193-4en_US
dc.identifier.doi10.23736/S2724-5276.21.06193-4en_US
dc.identifier.pmid33858131en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1698
dc.identifier.wosWOS:001146337200001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAltuner Torun, Yasemin
dc.language.isoenen_US
dc.relation.ispartofMinerva Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidant Capacityen_US
dc.subjectIron Deficiencyen_US
dc.subjectIron-deficiency Anemiaen_US
dc.subjectCarotid Intimamedia Thicknessen_US
dc.titleReduced antioxidant capacity in children with iron deficiency and iron-deficiency anemiaen_US
dc.typeArticleen_US

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