Follow-up for patients with intestinal metaplasia restricted to the antrum

Basit Öğe Kaydı
dc.authoridYeşim Saliha Gürbüz / 0000-0002-4278-8241en_US
dc.authorscopusidYeşim Saliha Gürbüz / 7004052030
dc.authorwosidYeşim Saliha Gürbüz / CRQ-9252-2022
dc.contributor.authorKoç, Deniz Öğütmen
dc.contributor.authorHülagü, Sadettin
dc.contributor.authorGürbüz, Yeşim Saliha
dc.contributor.authorÇelebi, Altay
dc.contributor.authorDuman, Ali Erkan
dc.contributor.authorKazaz, Tanyeli Güneyligil
dc.date.accessioned2021-01-25T07:04:23Z
dc.date.available2021-01-25T07:04:23Z
dc.date.issued2020en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: Guidelines recommend endoscopic surveillance for patients with extensive atrophy/intestinal metaplasia (IM), but follow-up is not recommended for patients with atrophy/IM restricted to the antrum. We evaluated the risk of neoplastic lesions in patients with antrum-restricted IM to determine whether surveillance endoscopy is necessary. Methods: Overall, 117 patients with antrum-restricted IM diagnosed within the past 10 years underwent surveillance endoscopy. The gastric biopsy specimens were evaluated for atrophy, IM, and dysplasia. Results: We enrolled 117 patients. Surveillance endoscopy was performed at a median (interquartile range) of 7.2 years (5.9-8.7 years) after the initial diagnosis of IM. On surveillance endoscopy, 27.4% of patients exhibited progression in their IM grade, whereas 25.6% had atrophy progression, and 33.3% had dysplasia progression. High-grade dysplasia and gastric cancer (GC) were detected in four and two patients, respectively. The annual incidence of GC in patients with antrum-restricted IM was 0.17%. IM grade and type regressed in 29.9% and 38.5% of patients, respectively. Most patients with progressive IM grade, IM type, and dysplasia on surveillance endoscopy had Operative Link on Gastritis Assessment (OLGA) stage 3-4 (p=0.0001, p=0.008, and p=0.0001, respectively), and most patients with progressive atrophy and dysplasia had Operative Link on Gastric IM (OLGIM) stage 3-4 (both p=0.001). Conclusion: Patients with IM restricted to the antrum are at risk for neoplastic lesions and require endoscopic surveillance, contrary to existing recommendations. Premalignant lesions can exhibit both progression and regression. Therefore, a patient-specific surveillance program based on OLGA and OLGIM might be appropriate.en_US
dc.identifier.citationKoç, D. Ö., Hülagü, S., Gürbüz, Y. S., Çelebi, A., Duman, A. E., & Kazaz, T. G. (2020). Follow-up for Patients with Intestinal Metaplasia Restricted to the Antrum. Journal of Academic Research in Medicine, 10(3).en_US
dc.identifier.doi10.4274/jarem.galenos.2020.3885en_US
dc.identifier.endpage276en_US
dc.identifier.issn2146-6505en_US
dc.identifier.issn2147-1894en_US
dc.identifier.issue3en_US
dc.identifier.startpage269en_US
dc.identifier.trdizinid417170en_US
dc.identifier.urihttps://doi.org/10.4274/jarem.galenos.2020.3885
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1363
dc.identifier.volume10en_US
dc.identifier.wosWOS:000604280800012en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorGürbüz, Yeşim Saliha
dc.language.isoenen_US
dc.publisherGALENOS YAYINCILIKen_US
dc.relation.ispartofJOURNAL OF ACADEMIC RESEARCH IN MEDICINE-JAREMen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGastric Canceren_US
dc.subjectIntestinal Metaplasiaen_US
dc.subjectSurveillance Endoscopyen_US
dc.titleFollow-up for patients with intestinal metaplasia restricted to the antrumen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
jarem-10-269-En.pdf
Boyut:
203.15 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Cerrahi Tıp Bilimleri Bölümü Makale Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu