Can intrapleural alteplase treatment be an alternative to videothoracoscopic deloculation and decortication in pleural empyema?

dc.authoridCebrail Azar / 0000-0002-1667-5454
dc.authorscopusidCebrail Azar / 57208282643
dc.authorwosidCebrail Azar / HDM-1507-2022
dc.contributor.authorKermenli, Tayfun
dc.contributor.authorAzar, Cebrail
dc.date.accessioned2021-10-07T07:19:41Z
dc.date.available2021-10-07T07:19:41Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Hastaneen_US
dc.description.abstractIntroduction: Chest tube drainage is the first step in the management of complicated pleural effusions that have turned into empyema. In cases where adequate drainage cannot be provided or deloculation is required, intrapleural fibrinolytic therapy or surgical deloculation can be performed. Alteplase is a suitable agent for intrapleural fibrinolytic therapy. On the other hand, video-assisted surgery is an effective and minimally invasive treatment option for lung re-expansion. Aim: The effect of intrapleural alteplase irrigation applied through the thoracic tube in the treatment of pleural empyema was investigated and whether it could be an alternative technique to video-assisted thoracoscopic surgery was evaluated. Material and methods: The results of patients who were treated for empyema in our clinic were evaluated retrospectively. Twenty-one patients who underwent tube thoracostomy + intrapleural alteplase and 28 patients who underwent VATS deloculation were included in the study. Results: The study included 35 male and 14 female patients. There were 21 patients in group 1, and 28 patients in group 2. The mean age was 50.6. The average length of thoracic tube stay was determined as 7.1 and 6.96 days. The duration of hospital stay in this group was 6.73 and 6.35 days. In 17 (81%) patients in group 1, the treatment was discontinued without the need for surgery. Conclusions: VATS-D is an effective option in the treatment of pleural empyema. However, as seen in our study, intrapleural alteplase application is at least as effective as VATS-D in terms of treatment success.en_US
dc.identifier.citationKermenli, T., & Azar, C. (2021). Can intrapleural alteplase treatment be an alternative to videothoracoscopic deloculation and decortication in pleural empyema?. Videosurgery and Other Miniinvasive Techniques, 16(1).en_US
dc.identifier.doi10.5114/wiitm.2021.103920en_US
dc.identifier.endpage586en_US
dc.identifier.issn1895-4588en_US
dc.identifier.issn2299-0054en_US
dc.identifier.issue3en_US
dc.identifier.pmid34691309en_US
dc.identifier.scopus2-s2.0-85116259519en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage580en_US
dc.identifier.urihttps://doi.org/10.5114/wiitm.2021.103920
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2124
dc.identifier.volume16en_US
dc.identifier.wosWOS:000700910200014en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAzar, Cebrailen_US
dc.language.isoenen_US
dc.publisherTERMEDIA PUBLISHING HOUSE LTDen_US
dc.relation.ispartofVIDEOSURGERY AND OTHER MINIINVASIVE TECHNIQUESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPleural Empyemaen_US
dc.subjectVideo-Assisted Thoracoscopic Surgeryen_US
dc.subjectIntrapleural Treatmenten_US
dc.subjectAlteplaseen_US
dc.subjectDeloculationen_US
dc.titleCan intrapleural alteplase treatment be an alternative to videothoracoscopic deloculation and decortication in pleural empyema?en_US
dc.typeArticleen_US

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