Coronary flow velocity reserve is reduced in patients with an exaggerated blood pressure response to exercise

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dc.authoridTolga Sinan Güvenç / 0000-0002-6738-266X
dc.authorscopusidTolga Sinan Güvenç / 6602421975
dc.authorwosidTolga Sinan Güvenç / AAK-6020-2020en_US
dc.contributor.authorBaycan, Ömer Faruk
dc.contributor.authorÇelik, Fatma Betül
dc.contributor.authorGüvenç, Tolga Sinan
dc.contributor.authorAtıcı, Adem
dc.contributor.authorYılmaz, Yusuf
dc.contributor.authorKonal, Oğuz
dc.contributor.authorAğırbaşlı, Mehmet
dc.contributor.authorKul, Şeref
dc.contributor.authorGüllü, Hakan
dc.contributor.authorÇalışkan, Mustafa
dc.date.accessioned2022-08-29T12:22:30Z
dc.date.available2022-08-29T12:22:30Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Hastaneen_US
dc.description.abstractCoronary artery disease and cardiovascular mortality are increased in patients with an exaggerated blood pressure response to exercise. The exact cause of this increase remains unknown, but previous studies have indicated the presence of endothelial dysfunction in peripheral arteries and subclinical atherosclerosis in these patients. The present study aimed to clarify whether coronary microvascular dysfunction is also present in patients with exaggerated blood pressure response to exercise. A total of 95 patients undergoing exercise testing were consecutively enrolled. Flow-mediated vasodilatation and carotid intima-media thickness were measured using standardized methods. A transthoracic echocardiography examination was performed to measure coronary flow velocity reserve. Patients with an exaggerated blood pressure response to exercise had significantly lower coronary flow velocity reserve than the controls (2.06 (1.91–2.36) vs. 2.27 (2.08–2.72), p = 0.004), and this difference was caused by a reduction in hyperemic flow velocity (57.5 (51.3–61.5) vs. 62.0 (56.0–73.0), p = 0.004) rather than a difference in basal flow (26.5 (22.3–29.8) vs. 26.0 (24.0–28.8), p = 0.95). Patients with an exaggerated blood pressure response to exercise also had a significantly greater carotid intima-media thickness and significantly lower flow-mediated vasodilatation than controls. However, an exaggerated blood pressure response to exercise remained a significant predictor of coronary microvascular dysfunction after adjusting for confounders (OR: 3.60, 95% CI: 1.23–10.54, p = 0.02). Patients with an exaggerated blood pressure response to exercise show signs of coronary microvascular dysfunction, in addition to endothelial dysfunction and subclinical atherosclerosis. This finding might explain the increased risk of coronary artery disease and cardiovascular mortality in these patients.en_US
dc.identifier.citationBaycan ÖF, Çelik FB, Güvenç TS, Atıcı A, Yılmaz Y, Konal O, Ağırbaşlı MA, Kul Ş, Güllü H, Çalışkan M. Coronary flow velocity reserve is reduced in patients with an exaggerated blood pressure response to exercise. Hypertens Res. 2022 Aug 19. doi: 10.1038/s41440-022-00995-0. Epub ahead of print. PMID: 35986188.en_US
dc.identifier.doi10.1038/s41440-022-00995-0en_US
dc.identifier.issn0916-9636en_US
dc.identifier.pmid35986188en_US
dc.identifier.scopus2-s2.0-85136468034en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttp://doi.org/10.1038/s41440-022-00995-0
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3110
dc.identifier.wosWOS:000843242600001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGüvenç, Tolga Sinan
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofHypertension Research : Official Journal of the Japanese Society of Hypertensionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHypertensionen_US
dc.subjectExerciseen_US
dc.subjectCoronary Artery Diseaseen_US
dc.subjectMicrovascular Dysfunctionen_US
dc.subjectEchocardiographyen_US
dc.titleCoronary flow velocity reserve is reduced in patients with an exaggerated blood pressure response to exerciseen_US
dc.typeArticleen_US

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