Apelin/APJ expression in the heart and kidneys of hypertensive rats

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dc.authoridFiliz Tepeköy Özçelik / 0000-0003-1901-3787
dc.authorscopusidFiliz Tepeköy Özçelik / 55982535300
dc.authorwosidFiliz Tepeköy Özçelik / AAF-4121-2020
dc.contributor.authorŞekerci, Rahime
dc.contributor.authorAcar, Nuray
dc.contributor.authorTepeköy Özçelik, Filiz
dc.contributor.authorÜstünel, İsmail
dc.contributor.authorKeleş Çelik, Nigar
dc.date.accessioned2020-08-30T20:07:53Z
dc.date.available2020-08-30T20:07:53Z
dc.date.issued2018
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractHypertension is an important health problem that is manifested by systemic arterial blood pressure being permanently elevated and leading to serious complications. Hypertension is the basis for coronary heart diseases, heart failure, kidney damage, cerebrovascular diseases. Due to ethical concerns, there is no detailed study of the mechanism, side effects and treatment of hypertension in humans. For this reason, specific studies related to the organ of hypertension are performed in experimental animals. The heart and kidney tissue, which are the most important organs that hypertension has damaged, have formed specific organs of our work. In our experimental study, a total of 35 (hypertensive group: 20, control group: 15) Rattus Norvegicus Wistar albino rats were used. In order to obtain our hypertension model, our experimental animals were given L-NAME together with drinking water for six weeks. After six weeks, the experimental procedures were terminated. Heart and kidney tissues of the hypertensive and control group were obtained. Expression of apelin and apelin receptor (APJ) was demonstrated by immunohistochemical and Western Blot protocols. Hypertrophic cardiac atrium of the hearts of the large cavities, interventricular septum and myocardium to the disintegration, as well as an increase in the diameter of the coronary artery has been observed. In general, kidney tissues of the hypertensive group showed narrowing in cortical renal structures and enlargement in structures in the renal medulla. As a result, in hypertensive cases, there was an increase in expression of Apelin and APJ receptor in heart tissue, and a decrease in expression of Apelin and APJ receptor in kidney tissue. We think that our findings may contribute to experimental or clinical studies related to hypertension and apelin.en_US
dc.description.sponsorshipScientific Research Projects Coordination Unit of Akdeniz UniversityAkdeniz University [2011.02.0122.007]en_US
dc.description.sponsorshipThis study is a part of a MSc thesis and supported by Scientific Research Projects Coordination Unit of Akdeniz University (grant number: 2011.02.0122.007).en_US
dc.identifier.citationSekerci, R., Acar, N., Tepekoy, F., Ustunel, I., & Keles-Celik, N. (2018). Apelin/APJ expression in the heart and kidneys of hypertensive rats. Acta Histochemica, 120(3), 196–204. https://doi.org/10.1016/j.acthis.2018.01.007en_US
dc.identifier.doi10.1016/j.acthis.2018.01.007en_US
dc.identifier.endpage204en_US
dc.identifier.issn0065-1281en_US
dc.identifier.issn1618-0372en_US
dc.identifier.issue3en_US
dc.identifier.pmid29395316en_US
dc.identifier.scopus2-s2.0-85041096516en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage196en_US
dc.identifier.urihttps://doi.org/10.1016/j.acthis.2018.01.007
dc.identifier.urihttps://hdl.handle.net/20.500.12713/848
dc.identifier.volume120en_US
dc.identifier.wosWOS:000431387600005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTepeköy Özçelik, Filizen_US
dc.language.isoenen_US
dc.publisherElsevier Gmbh, Urban & Fischer Verlagen_US
dc.relation.ispartofActa Histochemicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHypertensionen_US
dc.subjectL-Nameen_US
dc.subjectApelinen_US
dc.subjectHearten_US
dc.subjectKidneyen_US
dc.titleApelin/APJ expression in the heart and kidneys of hypertensive ratsen_US
dc.typeArticleen_US

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