Applications of Polyaniline-Based Molybdenum Disulfide Nanoparticles against Brain-Eating Amoebae

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dc.authoridKhan, Naveed/0000-0001-7667-8553
dc.authoridSiddiqui, Ruqaiyyah/0000-0001-9646-6208;
dc.authorwosidKhan, Naveed/AAM-2892-2021
dc.authorwosidSiddiqui, Ruqaiyyah/AIF-2100-2022
dc.authorwosidAhmad, Irfan/C-6523-2019
dc.authorwosidKhan, Naveed/KCK-0156-2024
dc.contributor.authorAbdelnasir, Sumayah
dc.contributor.authorMungroo, Mohammad Ridwane
dc.contributor.authorChew, Jactty
dc.contributor.authorSiddiqui, Ruqaiyyah
dc.contributor.authorKhan, Naveed Ahmed
dc.contributor.authorAhmad, Irfan
dc.contributor.authorShahabuddin, Syed
dc.date.accessioned2024-05-19T14:50:33Z
dc.date.available2024-05-19T14:50:33Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractPrimary amoebic meningoencephalitis and granulomatous amoebic encephalitis are distressing infections of the central nervous system caused by brain-eating amoebae, namely, Naegleria fowleri and Acanthamoeba spp., respectively, and present mortality rates of over 90%. No single drug has been approved for use against these infections, and current therapy is met with an array of obstacles including high toxicity and limited specificity. Thus, the development of alternative effective chemotherapeutic agents for the management of infections due to brain-eating amoebae is a crucial requirement to avert future mortalities. In this paper, we synthesized a conducting polymer-based nanocomposite entailing polyaniline (PANI) and molybdenum disulfide (MoS2) and explored its anti-trophozoite and anti-cyst potentials against Acanthamoeba castellanii and Naegleria fowleri. The intracellular generation of reactive oxygen species (ROS) and ultrastructural appearances of amoeba were also evaluated with treatment. Throughout, treatment with the 1:2 and 1:5 ratios of PANI/MoS2 at 100 mu g/mL demonstrated significant anti-amoebic effects toward A. castellanii as well as N. fowleri, appraised to be ROS mediated and effectuate physical alterations to amoeba morphology. Further, cytocompatibility toward human keratinocyte skin cells (HaCaT) and primary human corneal epithelial cells (pHCEC) was noted. For the first time, polymer-based nanocomposites such as PANI/MoS2 are reported in this study as appealing options in the drug discovery for brain-eating amoebae infections.en_US
dc.description.sponsorshipMinistry of Higher Education Malaysia [FRGS/1/2018/SKK08/SYUC/01/1]; Scientific Research Deanship at King Khalid University; Large Research Group Project [RGP.02/186/-43]en_US
dc.description.sponsorshipFunding The work was supported by the Ministry of Higher Education Malaysia (FRGS/1/2018/SKK08/SYUC/01/1) . The authors also acknowledge the Scientific Research Deanship at King Khalid University for their support through the Large Research Group Project (RGP.02/186/-43) .en_US
dc.identifier.doi10.1021/acsomega.2c06050
dc.identifier.issn2470-1343
dc.identifier.pmid36910978en_US
dc.identifier.scopus2-s2.0-85149000547en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org10.1021/acsomega.2c06050
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5745
dc.identifier.wosWOS:000937585300001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAmer Chemical Socen_US
dc.relation.ispartofAcs Omegaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectHigh Antibacterial Activityen_US
dc.subjectFree-Living Amebasen_US
dc.subjectAntimicrobial Activityen_US
dc.subject2-Dimensional Mos2en_US
dc.subjectNaegleria-Fowlerien_US
dc.subjectExfoliated Mos2en_US
dc.subjectIn-Vitroen_US
dc.subjectAcanthamoebaen_US
dc.subjectChitosanen_US
dc.subjectCytotoxicityen_US
dc.titleApplications of Polyaniline-Based Molybdenum Disulfide Nanoparticles against Brain-Eating Amoebaeen_US
dc.typeArticleen_US

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